中药与多柔比星化疗联合运用的增效减毒作用

Synergistic and Attenuated Effects of Traditional Chinese Medicines on Doxorubicin Chemotherapy

多柔比星作为蒽环类药物的一员,被广泛应用于肿瘤化疗中,但其明显的心脏毒性及细胞毒性作用在一定程度上限制了其运用。如何提高多柔比星化疗效果及减轻其不良反应是目前值得探索的课题。本文试图从临床和实验的角度,对新近15年来中药与多柔比星联合运用方面的研究进展进行评析,以为临床运用提供参考。

Doxorubicin as a member of the anthracycline - based drugs, is widely used in cancer chemotherapy, while its signifi- cant cardiac toxicity and cytotoxicity limit its application to some extent. Therefore, it＇s a valuable exploring topic on how to improve the effect and reduce the adverse drug reactions of doxorubiein chemotherapy. This paper attempted to analyze the literatures about TCM combined with doxorubicin in nearly 15 years, including clinical use and experimental studies, to provide reference for the clinical ap- plication.