丹参多酚酸盐联合常规治疗急性脑梗死疗效及对血清白细胞介素-6影响观察

Effect of Salvianolate Combined with Conventional Therapy on Acute Ischemic Stroke and Influence on Serum Interleukin-6

目的:观察丹参多酚酸盐联合常规治疗对急性脑梗死患者的疗效及对血清炎性因子白细胞介素-6(IL-6)的影响。方法:70例急性脑梗死患者随机分为观察组和对照组各35例,均给予脑梗死常规治疗,观察组在此基础上加用丹参多酚酸盐注射液200 mg+0.9%氯化钠注射液250 ml,ivd,qd。两组疗程均为2周。另选取30例健康体检者为健康对照组。分别于治疗第3天、第7天、第10天及第14天评定两组患者神经功能缺损评分(NIHSS评分);于发病24 h内,治疗第3天、第7天、第10天及第14天检测两组患者血清IL-6水平,并与健康对照组的血清IL-6水平相比较。结果:治疗第7天开始观察组NIHSS评分较入院时显著下降(P<0.05),此后NIHSS评分持续下降;对照组NIHSS评分则在治疗第10天开始显著下降(P<0.05)。治疗第7天后,观察组NIHSS评分均显著低于对照组同期(P<0.05)。两组入院24 h内血清IL-6水平均显著高于健康对照组(P<0.05)。观察组血清IL-6水平从治疗第7天开始逐渐下降,治疗第14天时与健康对照组差异无统计学意义(P>0.05)。对照组血清IL-6水平在治疗第10天后逐渐下降,但对照组各时段血清IL-6水平均高于健康对照组(P<0.05)。治疗第7天开始观察组血清IL-6水平明显低于对照组(P<0.05);且观察组血清IL-6水平最高值明显低于对照组最高值(P<0.05)。结论:丹参多酚酸盐联合常规治疗能有效降低脑梗死患者NIHSS评分,降低其血清IL-6水平,效果优于单纯常规治疗。

Objective： To explore the effect of salvianolate combined with the conventional therapy on acute ischemic stroke and observe the influence on serum inflammatory cytokines of interleukin-6 （IL-6）. Methods： According to the random number table, 70 patients were randomly divided into the observation group （ n = 35） and the control group （ n = 35）, and both were given the conven- tional therapy for acute ischemic stroke. The observation group was given intravenous injection of 200mg salvianolate in 250ml normal saline once a day additionally. The treatment course was 2 weeks. Another 30 persons with physical examination were in the healthy control group. The neurologic damage deficiency score （NIHSS score） was evaluated after the 3-, 7-, 10- and 14-day treatment in the groups, the serum IL-6 in 24 h after onset, and after the 3-, 7-,10- and 14-day treatment was detected and compared with that in the healthy control group. Results： After the 7-day treatment, NIHSS score in the observation group decreased significantly when compared with that on admission （P 〈0.05）, and remained the decreasing trend. After the 10-day treatment, NIHSS score in the control group decreased significantly when compared with that on admission （P 〈 0.05）. After the 7-day treatment, NIHSS score in the observation group was lower than that in the control group （ P 〈 0.05 ）. Compared with that in the healthy control group, the serum level of IL-6 in the observation group and the control group was higher in 24 h of admission （ P 〈 0.05 ）. The serum level of IL-6 in the observation group decreased after the 7-day treatment, and was similar to that in the healthy control group after the 14-day treatment （P 〉 0.05）. The serum level of IL-6 in the control group decreased after the 10-day treatment, while was higher than that in the healthy control group during the whole study period （P 〈 0.05）. The serumlevel of IL-6 in the observation group was lower than that in the control group after the 7-day treatment （ P 〈 0.05 ）, and the peak value in the observation group was notably lower than that in the control group （P 〈 0.05 ）. Conclusion： Salvianolate combined with the conventional therapy can effectively decrease the NIHSS score and the content of IL-6 in the patients with acute ischemic stroke, which shows better effect than the conventional therapy alone.