血栓弹力图在急性冠脉综合征患者凝血监测中的应用价值被引量：5

Application Value of Thromboelastography in Coagulation Monitoring for ACS Patients

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摘要目的:探讨血栓弹力图(TEG)在急性冠脉综合征(ACS)患者凝血监测中的应用价值。方法:采用回顾性研究方法,收集经皮冠状动脉介入治疗(PCI)术后行TEG监测的ACS患者255例,分为非ST段抬高急性心肌梗死组(NSTEMI)、ST抬高性急性心肌梗死组(STEMI),TEG分析两组患者的凝血特点。结果:ACS患者有着较高的血栓强度(MA)和Angle角,STEMI患者的D-D二聚体、血小板强度(MA)较NSTEMI患者显著升高(P<0.01)。同时,STEMI患者的用药情况更符合指南要求。结论:TEG能够较好的反映ACS患者的血液高凝状态。其中,MA值和Angle角为预测高凝状态较敏感的指标。 Objective： To investigate the application value of thrombelastography （TEG） in coagulation monitoring for ACS pa- tients. Methods： Totally 255 ACS patients were selected with coagulation monitoring by TEG. The patients were divided into none ST- segment elevation myocardial infarction （NSTEMI） group and ST-segment elevation myocardial infarction （STEMI） group. The clotting characteristics in different types of ACS patients were compared and analyzed. Results： The ACS patients had higher intensity of thrombosis （MA） and Angle value. D-dimer and MA were significantly different between NSTEMI group and STEMI group （P 〈 0.01 ）. The drug utilization in STEMI group was closer to the requirements of the guidelines. Conclusion： TEG shows high application value in coagulation monitoring for ACS patients. MA value and Angle value are more sensitive in evaluating hypercoaguable state.

作者魏安华顾智淳刘东李娟

机构地区华中科技大学同济医学院附属同济医院药学部上海交通大学医学院附属仁济医院药剂科

出处《中国药师》 CAS 2017年第8期1431-1432,1456,共3页 China Pharmacist

关键词血栓弹力图急性冠脉综合征凝血功能 Thrombelastography ACS Coagulation function

分类号 R541.4 [医药卫生—心血管疾病]

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1杨海娜,王伟,卢绍禹,姜子恩.血栓弹力图(TEG)在冠心病凝血监测中的临床应用[J].实用心脑肺血管病杂志,2012,20(9):1455-1457. 被引量：24
2田文单,刘巍.血栓弹力图在心血管疾病中的应用价值[J].国际心血管病杂志,2012,39(1):39-40. 被引量：21

二级参考文献34

1Melrnikov VV, Melfnikova SL. Changes in the indices of the thrombelastogram at different phases of monthly rhythms [J]. Fiziol Cheloveka, 1994,20(4) : 171-173.
2Differding JA, Underwood SJ, Van PY, et al. First Place Residents' Competition: trauma induces a hypercoagulable state that is resistant to hypothermia as measured by thrombelastogram[J]. Am J Surg, 2011,201 (5) :585-589.
3Ruttmann TG, Lemmens HJ, Malott KA, et al. The haemodilution enhanced onset of coagulation as measured by the thrombelastogram is transient[J]. Eur J Anaesthesiol, 2006,23 (7) : 574-579.
4Karoutsos S, Nathan N, Lahrimi A,et al. Thrombelastogram reveals hypercoagulability after administration of gelatin solution[J]. Br J Anaesth, 1999,82(2):175-177.
5Moallempour M, Jahr JS, Lim JC, et al. Methemoglobin effects on coagulation: a dose-response study with HBOC-200 (Oxyglobin) in a thrombelastogram model[J]. J Cardiothorae Vasc Anesth, 2009,23(1) :41-47.
6Tantry US, Bliden KP, Gurbel PA. Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation [J]. J Am Coil Cardiol, 2005, 46(9) : 1705-1709.
7Hobson AR, Qureshi Z, Banks P, et al. Effects of clopidogrel on "aspirin specific" pathways of platelet inhibition [ J ]. Platelets, 2009, 20 (6) : 386-390.
8Differding JA, Underwood SJ, Van PY, et al. First Place Residentsr Competition: trauma induces a hypercoagulable state that is resistant to hypothermia as measured by thrombelastogram [J]. Am J Surg, 2011,201(5) :585-589.
9Pittman JR, Koenig A, Brainard BM. The effect of unfraetionated heparin on thrombelastographie analysis in healthy dogs [J]. J Vet Emerg Crit Care (San Antonio), 2010,20(2) :216-223.
10Moallempour M, Jahr JS, Lim JC, et al. Methemoglobin effects on coagulation: a dose-response study with HBOC- 200 (Oxyglobin) in a thrombelastogram model [ J ]. J Cardiothorae Vase Anesth, 2009,23(1) :41-47.