米非司酮在库欣综合征中的应用1例及相关指南复习

Application of Mifepristone in One Case of Cushing's Syndrome and Review of Related Guidelines

目的:探讨米非司酮在库欣综合征患者中的疗效以及不良反应的发生情况,为临床用药提供依据。方法:对药师参与的1例库欣综合征患者采用米非司酮治疗的病例进行分析。结果:米非司酮可以显著改善患者的高皮质醇血症及并发症,但应注意患者低血糖的风险,及时停止胰岛素治疗。结论:米非司酮应用于库欣综合征患者可以显著降低血糖水平,改善库欣容貌,但同时需密切监测血钾水平,警惕低钾血症的发生。

Objective： To investigate the efficacy of mifepristone in patients with Cushing＇s syndrome and the incidence of adverse reactions to provide basis for its clinical use. Methods： One case of Cushing＇s syndrome treated with mifepristone participated by phar- macist was analyzed. Results： Mifepristone could significantly improve hypedipidemia and the complications of the patient, mean- while, the risk of hypoglycemia should be paid attention and insulin therapy should be withdrawn timely. Conclusion： Mifepristone can significantly reduce blood glucose levels and improve the appearance of Cushing. At the same time, the level of serum potassium needs close monitoring to avoid the occurrence of hypokalemia.