翻白草的一般药理学研究

Study on the General Pharmacology of Potentill Discolor Bung

目的:研究翻白草对受试动物各系统的作用,为全面评定翻白草的安全性影响提供佐证。方法:将翻白草分别给予小鼠、大鼠口服,观察其对动物各系统的影响。记录翻白草对动物的一般药理学作用。结果:供试品给予小鼠后无异常行为,供试品与阈下剂量戊巴比妥钠无协同催眠影响,对其自发活动及协调作用没有影响(P>0.05),对大鼠的心血管系统及呼吸系统也无明显影响(P>0.05)。结论:在规定的水平剂量下,翻白草符合一般药理学规定。

Objective： To study the effects of potentill on all systems of experimental animals to provide experimental evidence for the comprehensive safety evaluation of potentiU. Methods： Mice and rats were given potentill orally to determine the influence on all systems, and the general pharmacological activities of potentill were recorded. Results： The general behavior of mice was normal after the adminisration of potentill, the test samples showed no synergetie hypnotic effect with nembutal at subthreshold dose, and had no in- fluence on the spontaneous activity and body coordination ability of mice （ P 〉 0.05 ）. The test samples showed no obvious influence on the cardiovascular system and respiratory system of rats （ P 〉 0.05 ）. Conclusion： Potentill meets the general requirements of pharma- cology at the prescribed dose.