黄酮类物质预防骨质疏松症的研究进展

Research Progress into the Prevention of Osteoporosis Using Flavonoids

随着我国步入老龄化社会,骨质疏松症屡见不鲜,已经成为严峻的公共卫生及社会问题。老年人骨含量降低,易导致骨脆性、骨折风险度上升,所以骨质疏松症应该及时诊断。但骨质疏松症治疗的难点在于治疗滞后,骨质病变前期的临床现象不易被发现,如何有效预防骨质疏松症成为医学界亟待解决的问题。黄酮类物质广泛存在于蔬菜、水果和药用植物中,含量丰富,具有多种生物活性,毒副作用小。大量研究证明,黄酮类物质可以促进成骨细胞增殖、促进骨细胞矿化、抑制破骨细胞骨吸收、增加骨峰值、减少骨流失,可有效预防骨质疏松症,保护骨健康。本文重在总结黄酮类物质防止骨质疏松症的分子机制、黄酮类物质预防骨质疏松症作用机理等研究进展,为预防骨质疏松症的保健食品和药品的开发提供理论依据。

As China is becoming an increasingly aging society, osteoporosis is very common and has become a serious public health and social problem. Decreased bone content in the elderly leads to bone fragility and increases fracture risk, so osteoporosis should be promptly diagnosed. However, the treatment of osteoporosis lags behind that of other chronic illnesses, the clinical phenomenon of early bone lesions is not easy to identify, and the effective prevention of osteoporosis has become an urgent problem to be solved by the medical field. Flavonoids are found widely in vegetables, fruits, and medicinal plants, and have a variety of bioactivities with few side effects. A large number of studies have shown that flavonoids can prevent osteoporosis and protect bone health by promoting osteoblast proliferation and osteocyte mineralization, inhibiting osteoclastic bone resorption, increasing peak bone mass, and reducing bone loss. This article focuses on reviewing research progress into the cellular and molecular mechanisms of action of flavonoids in preventing osteoporosis. This provides a theoretical basis for the development of functional foods and medicines for the prevention of osteoporosis.