宫颈低度鳞状上皮内瘤变与Ki-67阳性指数的相关性

Relationship between cervical CINⅠ and the positive index of Ki-67

目的研究宫颈低度上皮内瘤变(CINⅠ)与细胞增殖指数(Ki-67)阳性指数的相关性。方法选取我院妇科门诊100例宫颈活检诊断为宫颈低度上皮内瘤变的患者,同时检测免疫组化Ki-67,未经任何治疗,半年后病理活检及免疫组化检测Ki-67。前后病理及免疫组化Ki-67结果比对,统计患者的转变情况。结果首次宫颈活检诊断为CINⅠ的患者有100例,同时检测患者Ki-67阳性指数。将100例CINⅠ患者按Ki-67阳性率分为3个区间,阳性率小于3%的88例,3%~10%的10例,大于10%的2例,差异有统计学意义(P<0.05)。Ki-67阳性率小于3%的患者第2次活检病理显示病情基本无进展,3%~10%的10例患者有8例发展为CINⅡ,大于10%的2例患者全部发展为CINⅢ。结论 Ki-67阳性指数直接决定宫颈低度鳞状上皮内瘤变患者的转归,阳性指数越高越容易发展为CINⅡ或CINⅢ。

Objective To explore correlation of cervical low-alcohol intraepithelial neoplasia （CIN I） with positive index Ki-67. Methods A total of 100 patients with cervical hypothelial neoplasm were diagnosed of cervical biopsy in our hospital. The immunohistochemical ki-67 was detected with no treatment. The histopathological biopsy and immunohistochemical detection ki-67 were examined in 6 months. The pathologic biopsy and immunohistochemical ki-67 results were compared. Results In the first cervical biopsy, 100 patients were diagnosed of CIN I. The ki-67 positive index was detected. According to the positivity rate, 100 cases of CIN I were divided into 3 Ki-67 ranges：88 cases were less than 3%, 10 cases in 3%-10% and 2 cases were more than 10% （P〈0.05）. Patients with a positive rate less than 3% in the second biopsy showed no progress of disease. Eight cases in 3%-10% were developed for CIN Ⅱ. 2 cases in group of more than 10% were developed for CIN Ⅲ. Conclusion Ki-67 positive index can decide the cervical low-alcohol intraepithelial neoplasia outcome of patients. The high positive index make it develop for CIN Ⅱ or CIN Ⅲ.