Krüppel样转录因子家族在阿尔茨海默病发病机制中的作用研究进展

The Progress of Krüppel-like Factor Family in Pathogenesis of Alzheimer's Disease

阿尔茨海默病(AD)是一种中枢神经系统退行性疾病,主要病理特征是脑内β淀粉样蛋白沉积形成的老年斑和tau蛋白异常磷酸化后形成的神经纤维缠结。近年研究发现,Krüppel样转录因子在AD病理生理中扮演着不可或缺的角色,这些转录因子家族成员在细胞生长、分化、增殖、迁移、凋亡、代谢和炎症反应中具有多种调节功能。最新证据表明Krüppel样转录因子参与AD的发生发展。文中详细综述了Krüppel样转录因子家族在AD发病机制中的最新作用及其相关研究进展。

Alzheimer＇s disease（AD） is a degenerative disease of the central nervous system, the main pathological features of the brain β-amyloid（Aβ） deposition formation of age spots and tau abnormal phosphorylation after the formation of nerve fiber entanglement. In recent years, Krüppellike factor plays an indispensable role in AD pathophysiology. These zinc finger transcription factor family members in cell growth, differentiation, proliferation, migration, apoptosis, metabolism andinflammation have a variety of regulatory functions. Recent evidences suggested that Krüppellike transcription factors were involved in the pathogenesis of AD. The role of the Krüppel-like transcription factor family in the pathogenesis of AD and its associated progression were reviewed.