前列腺特异性启动子在溶瘤腺病毒中的应用

Application of prostate-specific promoter in oncolytic adenovirus

前列腺癌是老年男性高发性肿瘤疾病。运用雄激素去势治疗早期可以有效的抑制肿瘤生长,但2~3年后大部分前列腺癌进展为去势抵抗性前列腺癌,导致患者死亡。去势抵抗性前列腺癌目前缺乏有效的治疗手段,溶瘤腺病毒是近年来肿瘤基因治疗的热点,也是前列腺癌治疗的新方法。运用特异性的启动子控制关键基因的表达是腺病毒改造的重要策略,能进一步提高抗肿瘤作用的特异性和人体的安全性。本研究对前列腺特异性启动子在溶瘤腺病毒中的应用进行综述。

Prostate cancer is a high-risk tumor in older men.Androgen deprivation therapy（ADT）can effectively inhibit tumor growth.After two or three years,prostate cancer progresses to castration-resistant prostate cancer（CRPC）,and cause death.CRPC lacks effective treatments.Oncolytic adenovirus is a hot spot in the field of tumor gene therapy in recent years,and is also a new treatment of prostate cancer.The way that specific promoter is used to control the expression of key genes is an important strategy in the recombination of adenovirus,and further improves the specificity of the anti-tumor effect and human safety.Prostate specific promoter that is applied in oncolytic adenovirus will be reviewed.