汉防己甲素对兔实验性动脉粥样硬化形成的影响

EFFECT OF TETRANDRINE ON CHOLESTEROL-INDUCED ATHEROSCLEROSIS IN RABBITS

家兔喂以高脂膳食复制动脉粥样硬化模型,并给予汉防已甲素。用LeitzASM68K型半自动图像分析系统检测主动脉病变面积,并对冠状动脉病变进行常规病理学检查。结果表明,汉防已甲素能抑制主动脉和冠状动脉动脉粥样硬化病变的发生,但对高脂血症无明显影响。

Twenty-four adult male Lop rabbits were equally divided into three groups. The unconditional group was fed standard pellets. Whereas the control and cxperimental groups were fed a diet containing 1% cholesterol and 3 lard for up to l0 weeks, and the latter was treated with tetrandrine concomitantly. The aortas were stained with Sudan black and the area of atherosclerotic lesions were measured with Leitz ASM 68K semi-automatic image analysis system. The results showed that the area of atherosclerotic lesions of the experimental group was significantly smaller than that of the control group. Microscopically, atherosclerotic lesions in the intramural coronary artery in 4 of 8 animals of the control group while none in animals of the experimental group were found. Serum cholesterol levels of animals of the control and experimental groups were significantly higher than that of the unconditional group, but there was no significant difference between the former two. The results sugsest that tetrandrine could suporess atherogenesis in cholesterol-fed rabbits, but has no effect on hyperlipidemia. The mechanism of tertrandrine on athero genesis was discussed.