柴胡疏肝散化裁联合雷贝拉唑肠溶片治疗胃食管反流病临床观察

Clinical Observation on Bupleurum Liver-Soothing Powder Combining with Rabeprazole Sodium Enteric-coated Tablets for the Treatment of Gastro-esophageal Reflux Disease

目的:观察柴胡疏肝散化裁联合雷贝拉唑肠溶片治疗胃食管反流病的临床疗效。方法:选择2013年3月至2015年4月在本院就诊的90例胃食管返流病患者,按照随机数字表法将成对照组和治疗组各45例。对照组给予雷贝拉唑肠溶片,治疗组在对照组基础上给予予以中医柴胡疏肝散化裁治疗,治疗4周为1疗程,共2个疗程。观察2组临床症状积分、临床疗效、食管黏膜病变分级、不良反应和复发率。结果:治疗后,治疗组患者烧心、反酸、胸闷不适和反食积分显著低于对照组(P<0.05);治疗组总有效率为90.2%,显著高于对照组73.6%,差异有统计学意义(χ~2=4.87,P<0.05);治疗组食管黏膜病变分级改善情况优于对照组,差异有统计学意义(P<0.05);2组不良反应较低,且差异无统计学意义(P>0.05)。治疗3个月后,治疗组复发率为6.67%,显著低于对照组26.67%(χ~2=6.48,P<0.05)。结论:柴胡疏肝散化裁联合雷贝拉唑肠溶片治疗胃食管反流病有良好临床疗效,明显优于雷贝拉唑肠溶片,值得临床推广。

Objective： To observe the clinical effect of bupleurum Liver-Soothing Powder combining with Rabeprazole Sodium Enteric-coated Tablets for treating gastro-esophageal reflux disease. Methods： A total of 90 patients with gastro-esophageal reflux disease in our hospital from March 2013 to April 2015 were selected and randomly divided into the control group（ 45 patients） and the treatment group（ 45 patients）. The control group had Rabeprazole Sodium Enteric-coated Tablets,while the treatment group had bupleurum Liver-Soothing Powder on the basis treatment of the control group. The treatment lasted for 2 course,a course lasted for4 weeks. The clinical symptom integral,the clinical curative effect,the esophageal mucosal lesions classification,the adverse reactions and the recurrence rate were compared between the groups. Results： After treatment,the treatment group of heartburn integrals,anti-acid integrals,chest discomfort integrals and anti-food integrals were significantly lower than the control group（ P〈0. 05）. The total effectiveness of the treatment group was 90. 2 %,which was significantly higher than the control group 73. 6%,and the difference was statistically significant（ χ^2= 4. 87,P〈0. 05）. The treatment group esophageal mucosal lesions classification improved more comparing with the control group,and the difference was statistically significant（ P〈0. 05）. Both of the groups had less adverse reactions and the difference was not statistically significant（ P〈0. 05）. Three months later after the treatment,the treatment group recurrence rate was 6. 67%,it was significantly 26. 67% lower than the control group（ χ^2= 6. 48,P〈0. 05）. Conclusion： Bupleurum Liver-Soothing Powder with Rabeprazole Sodium Enteric-coated Tablets has significant effects on gastro-esophageal reflux disease,and is better than Rabeprazole Sodium Enteric-coated Tablets,worthwhile for spreading in clinical practice.