肝纤维化分子显像的研究进展

The research progress of molecular imaging of liver fibrosis

肝纤维化是一种伴随慢性肝病的病理过程，具有较高的发病率和病死率。目前诊断肝纤维化的金标准是肝活检术，但肝活检术有其局限性，且目前尚无有效的无创诊断肝纤维化的手段。在肝纤维化的早期阶段，其可通过治疗“逆转”，因此，肝纤维化的诊断和精确分期在控制该疾病中非常重要。由于分子影像学技术具有无创、特异度高等优点，因此其发展具有巨大潜力。笔者对磁共振分子影像学技术和核医学分子影像学技术在肝纤维化诊断和分期方面的最新进展进行概述。

Hepatic fibrosis is a pathological process associated with chronic liver diseases,with significant morbidity and mortality.The current gold standard for the diagnosis of liver fibrosis is liver biopsy,but liver biopsy has many limitations.Currently,there is no noninvasive means of effective diagnosis of liver fibrosis.In the early stages of the disease,it can be reversed by active therapy.Thus,diagnosis and precise stages of liver fibrosis are important in controlling progression of the disease.Because of its noninvasive,high specificity and other advantages,molecular imaging has great potential use in liver fibrosis.This paper provides an overview of the latest advances in the diagnosis and stages of liver fibrosis using magnetic resonance imaging and nuclear medicine imaging.