鼻中隔矫正术围术期抗生素使用情况的Meta分析与评价

Antibiotics in septoplasty:a systematic review

目的评价鼻中隔矫正术围术期抗生素使用情况,规范抗生素的使用,为临床合理使用抗生素提供参考。方法采用系统评价方法,通过检索数据库,收集国内外关于鼻中隔矫正术围术期不同抗生素使用情况的随机对照研究进行Meta分析。结果系统评价研究纳入6项随机对照试验,结果表明,在抗生素的给药时间上,无论是麻醉时给予一次的抗生素还是术后连续7 d给予抗生素,两组在发生术后感染、血肿或是脓鼻涕的风险上差异无统计学意义[相对危险度(RR)=0.98,95%可信区间(confidential interval,CI):0.61~1.56,P=0.93];在是否需要给予抗生素做预防用药的比较中,无论围术期是否使用抗生素,其发生术后感染、血肿或是脓鼻涕的风险上差异无统计学意义[相对危险度(RR)=1.32,95%CI:0.90~1.95,P=0.16]。结论鼻中隔矫正术术前使用1次抗生素与手术前后使用7 d的结果比较差异无统计学意义。

Objective To standardize the use of antibiotics and guide rational use of clinical drugs by evaluating the use of antibiotics for septoplasty. Methods Related articles were retrieved from both Chinese and English databases. Results There were six randomized controlled trials included in this study. Whether antibiotics were used during anesthesia or for seven consecutive days after operation did not lead to significant difference in the risks of incidence of postoperative infections,hematoma or purulent nasal discharge [relative risk（ RR） = 0. 98 95%,CI： 0. 61-1. 56,P = 0. 93]. Whether antibiotics were used or not during septoplasty had the same effect[relative risk（ RR） = 1. 32 95%,CI： 0. 90-1. 95,P = 0. 16]. Conclusions Meta-analysis has showed that no significant difference is found between the group that receives antibiotics once preoperatively and the group that takes antibiotics for 7 days postoperatively.