口腔黏膜下纤维化患者血清微量元素分析

Analysis of serum trace elements in patients with oral submucous fibrosis

目的:检测血清微量元素(Fe、Mg、Cu、Zn)在口腔黏膜下纤维化(oral submucous fibrosis,OSF)中的表达,并分析年龄因素对血清微量元素的影响。方法:选取73例临床及病理诊断为OSF中期的门诊患者,检测其血清微量元素Fe、Mg、Cu、Zn含量,并按20~30岁、30~40岁、>40岁年龄组分组比较年龄因素对患者血清微量元素的影响,选取20例健康志愿者为对照组。结果:OSF患者血清Fe含量明显高于对照组(P<0.05),而Mg、Cu、Zn含量与对照组差异无统计学意义(P>0.05);OSF各年龄组比较,血清Fe、Mg、Cu、Zn含量均无明显差异(P>0.05),各年龄组微量元素异常率比较,差异也无统计学意义(P>0.05)。结论:OSF患者血清Fe含量偏高,提示临床治疗OSF的同时,需密切关注血清Fe浓度变化情况,并结合血液流变学及贫血形态学检测结果,为寻找更加合理的治疗方案提供参考。

Objective：To detect the expression of trace elements （iron, magnesium, copper and zinc）in serum of pa- tients with oral submucous fibrosis ,and to analyze the influence of age on trace elements. Methods：A total of 73 clinic patients, clinical and pathological grades II of OSF, were detected serum levels of trace elements （iron, magnesium, copper and zinc） which were later compared by age of 20 - 30,30 - 40, over 40, and 20 healthy volunteers were chosen as control group in our hospital physical examination center. Results ： Serum iron levels were significantly higher than the control group （ P 〈0. 05 ） ,while serum magnesium, copper and zinc levels had no significant difference in both the groups （ P 〉 0. 05 ）. There were no significant difference among the serum levels of trace elements （ iron, magnesium, copper and zinc） of all the age groups （ P 〉 0. 05 ）, and the abnormal rate of every age group in the same way （ P 〉 0. 05 ）. Conclusion： Serum iron levels of patients with OSF were high,suggesting that we should pay close attention to the change of serum iron levels, and combine with the results of hemorheology and anemia morphology, to provide a more reasonable reference for treatment.