红景天对急性高海拔暴露下人体运动应激反应的作用研究

Effects of Rhodiola rosea on human stress responses under acute high altitude exposure

目的:探讨红景天对急性高海拔缺氧暴露人体运动前、后应激反应的作用。方法:8名受试者连续服用红景天7d和14d后急性暴露于模拟海拔4000 m的缺氧环境。服用红景天前、后进行自身对比体力负荷运动实验,并于运动前、后检测血浆多巴胺(dopamine,DA)、肾上腺素(epinephrine,E)、去甲肾上腺素(norepinephrine,NE)和促肾上腺皮质激素(adrenocorti cotrophic hormone,ACTH)水平。结果:机体在4000m暴露时安静和体力负荷后的DA、E、NE和ACTH水平均较海平对照值显著升高,差异具有统计学意义(P<0.05或P<0.01);服用红景天7d和14d再次4000m暴露体力负荷后的DA、NE、ACTH水平以及服药14d安静时的DA、NE水平均较4000m对照值显著降低,差异具有统计学意义(均P<0.01);服用红景天7d、14d再次急性高海拔暴露安静和体力负荷后的血浆E水平均较4000m对照值明显升高,差异具有统计学意义(均P<0.01)。结论:急性高海拔缺氧应激可使机体神经递质和激素水平上升,红景天能通过降低氧耗速度,增加机体氧供提高机体的抗缺氧能力,降低应激反应,从而加速人体对急性高海拔缺氧环境的习服,提高高海拔劳动能力。

Objective：To study the effects of Rhodiola rosea on human stress responses under simulated 4000 m acute high altitude in hypobaric chamber.Methods：Eight healthy men participated in this experiment,before and after 7,14 dRhodiola rosea taken,the dopamine（DA）,epinephrine（E）,norepinephrine（NE）and adrenocorti cotrophic hormone（ACTH）levels in blood plasma were detected before and after physical load.All subjects underwent steppingstool exercise for physical load（step height 30 cm,stepping-stool rate of 25 beats/min for 5 minutes）.Results：The DA,E,NE and ACTH levels at both rest state and after physical load were significantly higher than the sea level group,the differences were statistically significant（P〈0.05 or P〈0.01）;After 7,14 dRhodiola rosea taken,the DA,NE and ACTH levels after physical load were significantly lower than those in 4000 mgroup,and the DA,NE levels at rest state after 14 dRhodiola rosea taken were significantly lower than those in 4000 mgroup,the differences were statistically significant（P〈0.01）;The E contents at both rest state and after physical load were significantly higher than the 4000 m group,the differences were statistically significant（P〈0.01）.Conclusion：The acute high altitude stress could enhance the body neurotransmitter and hormone levels,the Rhodiola rosea could promote the body antihypoxia ability by reducing oxygen consumption and increasing the body＇s oxygen supply,thus to speed up the body acclimatization to hypobaric hypoxia and improve the labor ability at high altitude.