甲强龙和地塞米松预防剖宫产术后恶心呕吐的疗效对比分析

Prophylactic effect of methylprednisolone and dexamethasone on postoperative nausea and vomiting after cesarean section

目的比较甲强龙和地塞米松预防剖宫产术后恶心呕吐的临床疗效。方法择期剖宫产手术患者135例,按照随机数字表将患者随机分为3组,每组45例。M组:术毕静注甲强龙40 mg(2 mL);D组:术毕静注地塞米松8 mg(2 mL);N组:术毕静注生理盐水(2 mL)。观察术后24 h内恶心呕吐及救援止吐的情况。结果术后24 h内M组、D组、N组的PONV发生率分别为30.2%、34.9%、61.4%,M组、D组明显低于N组(P<0.05),但M组与D组之间差异无统计学意义(P>0.05),M组、D组、N组术后救援止吐率分别为9.3%、11.6%、34.1%,M组、D组明显低于N组(P<0.05),但M组与D组之间差异无统计学意义(P>0.05)。结论甲强龙、地塞米松单独使用均能有效预防剖宫产术后恶心呕吐的发生率,降低术后救援止吐率。

Objective To compare the clinical efficacy of methylprednisolone and dexamethasone in the pre- vention of nausea and vomiting after cesarean section. Methods One hundred and thirty-five patients scheduled for ce- sarean section were randomly divided into three groups with 45 cases in each group. Group M：post operation intrave- nous injection of methylprednisolone 40 mg （2 mL） ;group D：postoperative intravenous injection of dexamethasone 8 mg （2 mL） ;group N：intravenous injection of postoperative saline （2 mL）. The incidence of PONV and rescue antie- metic requirement within 24 h after operation were observed. Results The PONV incidences of group M,group D ,and group N were 30. 2% ,34. 9% ,and 61.4% ,group M and group D being significantly lower than that of group N （P 〈 0. 05 ）, but there was no significant difference between group M and group D （ P 〉 0. 05 ）. The rescue antiemetic rate of group M,group D,and group N was 9. 3% ,11.6% ,and 34. 1% ,group M and group D being significantly lower than that of group N （ P 〈 0. 05 ）, but there was no significant difference between group M and group D （ P 〉 0. 05 ）. Con- clusion Methylprecinisolone and dexamethasone alone can effectively prevent the nausea and vomiting after cesarean section and reduce the rate of postoperative antiemetic rescue.