普瑞巴林治疗糖尿病合并带状疱疹后神经痛的临床疗效观察

Effects of pregabalin on diabetes mellitus complicated with postherpetic neuralgia

目的探讨普瑞巴林对糖尿病合并带状疱疹后神经痛的临床治疗效果。方法将2016年6-12月期间在我院疼痛门诊治疗的糖尿病合并带状疱疹后神经痛患者48例随机分为观察组与对照组,每组24例。对照组给予口服盐酸羟考酮缓释片治疗,观察组给予口服盐酸羟考酮缓释片和普瑞巴林治疗。比较两组患者治疗前后视觉模拟评分(VAS)、SF-36量表评分、临床治疗有效率、不良反应及对血糖的影响。结果治疗4周后,两组患者VAS评分显著下降(P<0.05),观察组的VAS评分显著低于对照组(P<0.05);两组患者SF-36评分显著升高(P<0.05),观察组的SF-36评分显著高于对照组(P<0.05);观察组临床治疗有效率显著高于对照组(P<0.05);观察组中头晕、嗜睡的发生率较高,对照组中便秘发生率较高,两组不良反应比较差异具有统计学意义(P<0.05);两组患者的空腹血糖比较差异无统计学意义(P>0.05)。结论在常规口服盐酸羟考酮缓释片基础上加用普瑞巴林治疗糖尿病合并带状疱疹后神经痛,具有镇痛效果好、明显改善生活质量、不良反应少、对血糖影响小的优点。

Objective To investigate the clinical curative effect of pregabalin on diabetes mellitus complicated with postherpetic neuralgia. Methods A total of 48 cases of patients with diabetes mellitus and postherpetic neuralgia were selected,who were treated in our hospital from June to December in 2016, and they were randomly divided into control group and observation group. Patients in control group were treated with oxycodone, and patients in observation group were treated with oxycodone and pregabalin. The scores of visual analogue scale （ VAS ）, quality of life （ SF-36 scale） and clinical effective rate were compared between the two groups before and after treatment. Results After treatment, the VAS scores of the two groups were significantly decreased（ P 〈 0. 05 ） , and the VAS score of observation group was significantly lower than that of control group （ P 〈 0.05 ） ; the SF-36 scale scores were significantly increased （ P 〈 0.05 ）, and the score of observation group was significantly higher than that of control group （ P 〈 0. 05 ） ; the clin- ical effective rate of observation group was significantly higher than that of control group （ P 〈 0. 05 ） ; the incidence rate of dizziness and drowsiness in observation group was higher, while the rate of constipation was higher in control group, and there was statistical difference in the incidence of adverse reactions between the two groups （ P 〈 0. 05 ） ; there was no statistical difference in fasting glucose between the two groups of patients （ P 〉 0.05 ）. Conclusion Pregabalin can effectively improve the treatment effect of diabetes mellitus complicated with postherpetic neuralgia, and effectively re- lieve the pain and improve the quality of life with fewer adverse reactions and less influence on blood glucose.