摘要
利用超声辅助溶剂提取法,正、反相柱色谱及半制备HPLC等分离纯化手段,从植物北豆根中分离得到2个化合物,并利用核磁共振、质谱、红外光谱等对其进行结构鉴定,结果显示这2个化合物分别为蝙蝠葛啡碱(menisporphine)和蝙蝠葛宁碱(dauriporphine).活性实验结果表明,这2个化合物均具有较好的自由基清除活性,抑制率分别为99.8%和92.4%.本文实验结果可为抗氧化和抗老化药物的开发研究提供实验依据.
Two compounds were separated and purified from menispermum dauricum using ultrasonic-assisted solvent extraction technology,normal or reverse phase column chromatography and semi-preparative HPLC etc.Their structures were established by NMR,MS and IR spectroscopy experiments.The two compounds were determined as menisporphine（1）and dauriporphine（2）.Compounds 1 and 2 showed remarkable scavenging activity toward DPPH.Inhibition rate are 99.8% and 92.4%,respectively.The results of this paper provide experimental basis for the development of anti-oxidation and anti-aging drugs.
作者
衣涛
金英今
贾静杰
李熙峰
YI Tao JIN Yingjin JIA Jingjie LI Xifeng(Jilin Tobacco Industry Co. , Ltd. , Yanji 133000, China Department of Chemistry, College of Science, Yanbian University, Yanji 133002, China)
出处
《延边大学学报（自然科学版）》
CAS
2017年第2期128-130,共3页
Journal of Yanbian University（Natural Science Edition）
基金
吉林省科技发展计划项目(20140101044JC)
关键词
北豆根
自由基清除活性
蝙蝠葛啡碱
蝙蝠葛宁碱
menispermum dauricum
free radical scavenging activity
menisporphine
dauriporphine
