摘要
从濒危植物大别山五针松(Pinus dabeshanensis)松针(干重仅30 g)的90%甲醇提取物中分离得到10个二萜类化合物,其中新化合物dabeshanensin L(1)的结构是通过运用1D/2D NMR等波谱手段进行确证的.体外活性测试结果表明化合物isopimara-7-en-18-oic acid(4)、trans-abienol(6)和lambertianic acid(8)对蛋白酪氨酸磷酸酶1B(PTP1B)有显著的抑制作用,其IC_(50)值在14.6~37.7μmol/L之间.
One new, dabeshanensin L(1), and nine known diterpenoids with diverse structures were isolated from the 90% Me OH extract of the needles(30 g dried mass-limited samples) of Pinus dabeshanensis, an endangered conifer listed in the China Plant Red Data Book(CPRDB). The new structure was established by detailed analysis of its spectroscopic data(IR, 1D/2D NMR, HRMS). Among the isolates, isopimara-7-en-18-oic acid(4), trans-abienol(6), and lambertianic acid(8) showed significant inhibitory activities against the human protein tyrosine phosphatase 1B(PTP1B) enzyme, a key target for the treatment of type-Ⅱ diabetes and obesity, with IC50 values ranging from 14.6 to 37.7 μmol/L.
作者
李明
胡长玲
韩晗
熊娟
胡金锋
Li Ming Hu Changlin Han Han Xiong Juan Hu Jinfeng(Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第7期1860-1863,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21472021
81273401
81202420)
教育部高等学校博士学科点(博导类)基金(Nos.20120071110049
20120071120049)
国家重点基础研究发展规划(973计划
No.2013CB530700)资助项目~~