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红细胞分布宽度与冠心病合并阻塞性睡眠呼吸暂停患者严重程度的相关性

Red cell distribution width was associated with disease severity in coronary artery disease patients with obstructive sleep apnea syndrome
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摘要 目的探讨红细胞分布宽度(RDW)与冠心病合并阻塞性睡眠呼吸暂停(OSA)患者严重程度关系。方法将165例OSA患者根据睡眠呼吸暂停低通气指数(AHI)分为对照组(AHI<5次/h)37例,轻度OSA组(5≤AHI≤15次/h)35例,中度OSA组(15<AHI≤30次/h)50例,重度OSA组(AHI>30次/h)43例。采用血液分析仪测定患者RDW,同时采用胶乳增强免疫透射比浊法测定高敏C反应蛋白(hs-CRP)水平。比较不同组患者RDW和hs-CRP水平,分析RDW与OSA患者AHI相关性。结果重度组患者RDW(14.3%)明显高于中度组(13.6%)、轻度组(13.3%)和对照组(12.4%),四组之间比较差异有统计学意义,(P<0.05);对照组、轻度组、中度组和重度组患者hs-CRP水平分别为3.5、3.9、5.0和6.1 mg/L,组间差异有统计学意义(P<0.05);RDW与AHI、氧减指数、hs-CRP呈正相关(r值分别0.375、0.276和0.182,P均<0.05),Logistic回归分析显示RDW是OSA的独立危险因素之一(OR=1.56,95%CI:1.231~2.012,P<0.05)。结论 RDW是OSA的独立危险因素之一,并可作为OSA严重程度评价指标之一。 Objective To investigate the relationship between the red cell distribution width(RDW)and disease severity in coronary artery disease(CAD)patients with obstructive sleep apnea syndrome(OSA). Methods A total of 165 patients with confirmed CAD according to AHI were divided into four groups:control group(AHI〈5/h),mild group(5≤AHI≤15/h),moderate group(15〈AHI≤30/h)and severe group(AHI〉30/h). The RDW and high sensitivity C-reactive protein(hs-CRP) were measured by automated blood cell counter and Latex-enhanced immunity transmission turbidity method , respectively. The RDW values and levels of hs-CRP in different groups were compared ,and the correlation between RDW and AHI was analyzed. Results The RDW values were found to be higher in the severe OSAS group(14.3%)than in the control group(12.4%),mild group(13.3%)and moderate group(13.6%)and this was statistically significant(P〈0.001). When the four groups were compared ,severe group had the higher levels of hs-CRP[control group(3.5 mg/L),mild group (3.9 mg/L),moderate group(5.0 mg/L),and severe group(6.1 mg/L)]. There was a statistically significant correlation between RDW and AHI(r=0.375,P〈0.001),ODI(r=0.276,P〈0.001),and hs-CRP(r=0.182,P〈0.020). The multivariate Logistic regression analysis showed that RDW was one of the independent risk factors for OSA(OR=1.56,95%CI:1.231~2.012,P〈0.05). Conclusion The RDW could be used to indicate the diseaseseverity in patients with OSA.
作者 邱志辉 陆冬晓 伍颖欣 严惠婵 韦绮珊 QIU Zhi-hui LU Dong-xiao WU Ying-xin YAN Hui-chan WEI Qi-shan(Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Diseases, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou , Guangdong 510120, China)
出处 《热带医学杂志》 CAS 2017年第7期900-903,共4页 Journal of Tropical Medicine
基金 广东医学科研基金(A2016022)
关键词 阻塞性睡眠呼吸暂停 红细胞分布宽度 高敏C反应蛋白 Obstructive sleep apnea Red blood cell distribution width High sensitivity C-reactive protein
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