孕期幽门螺杆菌感染与妊娠合并症的相关性

Correlation between Helicobacter pylori infection during pregnancy and pregnancy complication

目的探讨孕期幽门螺杆菌感染与妊娠合并症的相关性。方法选取2014年2月至2016年2月就诊于本院妇产科门诊、在我院规律产检者120例。孕前幽门螺杆菌感染情况采用13C尿素呼气试验进行检测,试验结果阳性者为感染幽门螺杆菌(55例),纳入阳性组;阴性者为未感染(65例),从中随机选取55例纳入阴性组与阳性组进行统计学分析研究。观察两组患者各种妊娠相关并发症的发生情况及每日呕吐次数。结果阳性组产后出血发生率10.91%、胎盘粘连发生率18.18%、妊娠期糖尿病发生率18.18%、早产发生率7.27%、胎膜早破发生率(32.73%)、不良妊娠发生率(9.09%)、高血压疾病发生率(21.82%)以及贫血发生率(60.00%)均明显大于阴性组,差异有统计学意义(P<0.05)。阳性组患者每日呕吐3次发生率、每日呕吐4次发生率、每日呕吐>4次发生率均明显大于阴性组,阴性组患者每日无呕吐率、每日呕吐1~2次发生率均明显大于阳性组,阴性组呕吐强度强的患者及胃粘膜出血的患者明显少于阳性组,差异有统计学意义(P<0.05)。结论妊娠并发症与幽门螺杆菌感染有着紧密关联,孕前幽门螺杆菌的根除对减少妊娠相关并发症有效。

Objective To evaluate the effective of Helicobacter pylori（H. pylori）eradication before pregnancy on reducing pregnancy-related complications. Methods 120 outpatients admitted to our hospital for pre-pregnancy health clinical check up from February 2014 to February 2016 were selected for the study. Helicobacter pylori infection was detected by 13C urea breath test;55 cases were positive and 65 cases were negative. 55 cases were randomly selected from the negative group and analyzed together with those in the positive group.The incidence of pregnancy-related complications and daily vomiting were observed in both groups. Results The incidence of postpartum hemorrhage in the positive group was 10.91%,the incidence of placental adhesions was 18.18%,the incidence of gestational diabetes mellitus was 18.18%,the incidence of premature labor was 7.27%,the incidence of premature rupture of membranes was 32.73%,the incidence of adverse pregnancy was 9.09%,the occurrence of hypertension Rate was 21.82%and the incidence of anemia was significantly higher than 60.00%in the negative group,the difference was statistically significant（P〈0.05）. In the positive group,the incidence of vomiting 3 times per day,vomiting 4 times per day and vomiting more than 4 times a day were significantly higher than those in the negative group. In the negative group ,the incidence of vomiting for 1-2 times a day was significantly higher than that in the positive group. Patients with strong vomiting and gastric mucosal bleeding in the negative group was significantly less than that of the positive group（P〈0.05）.Conclusion There is a close association between multiple pregnancy complications and Helicobacter pylori infection,and the eradication of Helicobacter pylori before pregnancy is effective in reducing pregnancy-related complications.