肠易激综合征患者焦虑抑郁情绪与食物不耐受的相关性

Correlation analysis of anxiety and depression with food intolerance in Irritable Bowel Syndrome

目的 探讨肠易激综合征患者焦虑抑郁情绪与食物不耐受的相关性.方法 对168例肠易激综合征患者采集外周血进行食物不耐受IgG抗体检测,同时采用焦虑Zung氏焦虑自评量表、汉密顿焦虑量表评定焦虑状况,采用Zung氏抑郁自评量表、汉密顿抑郁量表评定抑郁状况,对测评结果进行统计分析.结果 本组患者食物不耐受发生率为60.7%,焦虑抑郁情绪检出率为59.5%;食物不耐受阳性患者焦虑抑郁各量表评分显著高于食物不耐受阴性患者（P〈0.01）,合并焦虑抑郁情绪患者食物不耐受阳性检出率（70.0%）显著高于无焦虑抑郁情绪患者（47.1%）（χ2=9.28,P〈0.01）.结论 肠易激综合征患者焦虑抑郁情绪及食物不耐受发生率高,焦虑抑郁等精神心理因素与患者食物不耐受的发生有一定的相关性,可能是造成食物不耐受发生的危险因素.

Objective To investigate the relationship between anxiety and depres sion with food intolerance in irritable bowel syndrome. Methods 168 patients with irritable bowel syndrome were selected and the level of food intolerance specific IgG antibodies in serum were measure by semiquantitative enzyme linked immunosorbent assay. Mental-psychological characteristics were measured with SAS,SDS, HAMD and HAMA. Statistical analysis was made on the evaluation results. Results The rate of food intolerance in irritable bowel syndrome was 60. 7% and the rate of anxiety and depression was 59.5%. The scores of SAS,SDS,HAMD and HAMA in food intolerance（＋） irritable bowel syndrome were significantly higher than that of food intolerance（-）irri table bowel syndrome（P〈0.01）. The rate of food intolerance in irritable bowel syndrome with anxiety and depression（70.0%） was higher than that of patients without anxiety and depression（47.1%） （x2 =9.28, P〈0. 010）. Conclusion Irritable bowel syndrome patients with anxiety and depression have a high inci- dence of food intolerance. There＇s a certain relevance between anxiety, depression and other mental patients with psychological factors and the occurrence of food intolerance, may be a risk factor for causing food intolerance.