温针灸联合综合护理对直肠癌患者行伊立替康化疗所致迟发性腹泻及焦虑抑郁情绪的影响

Influence of needle warming moxibustion and comprehensive nursing on delayed-onset diarrhea and anxiety-depressive mood in rectal cancer patients caused by irinotecan chemotherapy

目的 探讨温针灸联合综合护理对伊立替康所致直肠癌患者迟发性腹泻及焦虑抑郁情绪的影响.方法 将接受伊立替康化疗方案的62例直肠癌患者按随机数字表法分为观察组和对照组,每组31例,在常规护理基础上,对照组采用药物治疗,观察组采用温针施疚特定穴位和药物治疗.温针灸治疗后比较两组迟发性腹泻发生率、骨髓抑制发生率,采用焦虑自评量表及抑郁自评量表评定焦虑抑郁状况.结果 温针灸治疗后观察组迟发性腹泻发生率16.1%、骨髓抑制发生率19.4%,对照组分别为51.6%、58.1%,观察组显著低于对照组（P〈0.05）;观察组焦虑自评量表及抑郁自评量表评分显著低于对照组（P〈0.05）.观察组温针施灸过程中无明显不适发生.结论 温针灸能有效改善直肠癌患者行伊立替康化疗所致迟发性腹泻,减少化疗后骨髓抑制,降低化疗方案不能顺利实施的发生率,减轻患者焦虑抑郁情绪,提高治疗和护理依从性.

Objective To investigate the influence of needle warming moxibustion and comprehensive nursing on delayed-onset diarrhea and anxiety-depressive mood in rectal cancer patients caused by irinotecan chemotherapy. Methods 62 rectal cancer patients given irinotecan chemotherapy were selected and di- vided into observation group and control group according to random number table, 31 cases in each group. On the basis of routine nursing, control group was given drug therapy, observation group was given needle warming moxibustion and drug therapy. After treatment of needle warming moxibustion, occurrence rate of delayed-onset diarrhea, myelosuppression of the two groups were compared, anxiety-depressive mood condition was evaluated by self-rating anxiety scale and Self-Rating Depression Scale. Results After treatment of needle warming moxibustion, occurrence rate of delayed-onset diarrhea, myelosuppression of observation group and control group were 16.1~if0, 19.4G and 51.6G, 58.1~//00, observationgroup was obvi- ously lower than control group （P〈0.05）; scores of self-rating anxiety scale and Self-Rating Depression Scale o{ observation group was obviously lower than control group （P〈0.05）. No obvious discomfort occurred during needle warming moxibustion in observation group. Conclusion Needle warming moxibustion can effectively relieve delayed-onset diarrhea caused by irinoteean chemotherapy, reduce myelosuppression after chemotherapy, increase rate of smooth implementation, reduce anxiety-depressive mood and improve treatment and nursing compliance.