硫酸镁联合尼莫地平治疗妊娠期高血压综合征临床分析

Clinic analysis of magnesium sulfate combined with nimodipine in treating pregnancy-induced hypertension

目的 探讨硫酸镁联合尼莫地平对妊娠期高血压综合征患者的疗效以及母婴结局的影响.方法 将64例妊娠期高血压综合征患者按随机数字表法分为两组,每组32例,均予以硫酸镁治疗,研究组联合尼莫地平治疗,观察1个月.于治疗前后比较两组血压水平变化,临床疗效及母婴结局.结果 治疗后两组收缩压、舒张压均较治疗前显著下降（P〈0.01）,研究组收缩压、舒张压显著低于对照组（P〈0.01）;总有效率（90.6%）显著高于对照组（68.8%）（P〈0.05）;母婴结局中新生儿窒息率（3.1%）、产后出血率（3.1%）、早产率（6.3%）、剖宫产率（18.8%）均显著低于对照组（25.0%、25.0%、28.1%、46.9%）（P〈0.05）.结论 硫酸镁联合尼莫地平治疗妊娠期高血压综合征具有增效作用,疗效显著,能有效控制患者血压水平,改善母婴结局状况.

Objective To investigate the clinic effect of magnesium sulfate combined with nimodipine in treating pregnancy-induced hypertension and its influence on mother-infant prognosis. Methods 64 cases with pregnancy induced hypertension were selected and divided into two groups according to random num her table, 32 cases in each group, they were all given magnesium sulfate treatment, observation group was given magnesium sulfate combined with nimodipine, patients were observed for l month. Blood pressure level changes, clinic effect, mother-infant prognosis of the two groups before and after treatment was corn pared. Results Systolic and diastolic pressure of the two groups after treatment were significantly de clined （P〈0.01）, systolic and diastolic pressure of observation group were significantly lower than control group （P 〈0. 01） ; total efficiency of observation group （90.6%） was significantly higher than control group （68.8%） （P〈0. 05） ; newborn asphyxia rate, rate of postpartum hemorrhage, premature birth rate, cesarean section rate of observation group （3.1%, 3.1%, 6.3%, 18.8%） were all lower than control group （25.0%,25.0%,28.1%,46.9%） （P〈0. 05）. Conclusion Magnesium sulfate combined with nimodipine in treating pregnancy-induced hypertension has significant synergistic effect, it can lower blood pressure level and improve mother-infant prognosis condition.