依达拉奉联合托拉塞米对急性脑出血患者氧化应激、炎症因子、微循环及血液流变学的影响

Effects of edaravone combined tolosemide on oxidative stress,inflammatory factors,microcirculation and hemorheology in patients with acute cerebral hemorrhage

目的探讨依达拉奉联合托拉塞米对急性脑出血患者氧化应激、炎症因子、微循环及血液流变学的影响。方法采用随机数字法将132例急性脑出血患者随机分为2组,每组66例。对照组给予常规治疗,观察组在常规治疗基础上加用依达拉奉与托拉塞米。治疗后,比较2组患者氧化应激超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)及过氧化氢酶(CAT)、炎症因子采用酶联免疫吸附法测定C-反应蛋白(CRP)、肿瘤坏死因子(TNF-α)及白介素-2(IL-2)、微循环采用全自动血凝分析仪测定纤维蛋白原血(Fib)、血小板计数(PLT)、血小板聚集率(PAG)及血液流变学全血粘度高切、全血粘度中切、全血粘度低切、红细胞压积、红细胞聚集指数的变化。结果治疗后,2组SOD、GSH-Px、CAT水平明显升高(P<0.05),且观察组各水平显著大于对照组(P<0.05)。治疗后,2组炎症因子CRP、TNF-α水平明显降低(P<0.05),且观察组各水平显著低于对照组(P<0.05);2组抗炎因子IL-2升高(P<0.05),且观察组水平显著高于对照组(P<0.05)。2组Fib、PLT、PAG水平明显降低(P<0.05),且观察组各水平显著低于对照组(P<0.05)。治疗后,2组全血粘度高切、全血粘度中切、全血粘度低切、红细胞压积、红细胞聚集指数水平明显下降(P<0.05),且观察组各水平显著低于对照组(P<0.05)。结论依达拉奉联合托拉塞米可有效改善急性脑出血患者的氧化应激反应、炎症反应及血液流变学,促进血液微循环的循环速度。

Objective To investigate the effects of edaravone combined torasemide on oxidative stress,inflammatory factors, microcirculation and hemorheology in patients with acute cerebral hemorrhage. Methods One hundred and thirty- two patients with acute cerebral hemorrhage were randomly divided into two groups, each group 66 cases. The control group was given routine treatment, and the observation group was added edaravone and Torasemide based on control group. After treatment, the oxidative stress （ SOD, GSH-Px, CAT ）, inflammatory factors （ CRP, TNF-α, IL-2 ）, microcirculation （ Fib, PLT,PAG） and hemorheology（Blood viscosity at high Shear Rates,Blood viscosity at middle Shear Rates,Blood viscosity at low Shear Rates, Hematocrit, Erythrocyte aggregation index） of two groups were compared. Results After treatment, the SOD, GSH-Px and CAT levels of two groups were significantly increased （ P 〈 0.05 ） , and each indicator of observation group were significantly higher than those of control group （ P 〈 0.05 ）. After treatment, CRP and TNF-α levels of two groups were significantly reduced（ P 〈 0.05 ） , and each indicator of observation group were significantly lower than those of control group（ P 〈0. 05 ） ; IL-2 levels of two groups were significantly increased （ P 〈 0.05 ）, and IL-2 of observation group was significantly higher than that of control group（ P 〈 0.05 ）. The Fib, PLT and PAG levels of two groups were sig- nificantly decreased（P 〈0.05）, and each indicators of observation group were significantly lower than those of control group（P 〈 0. 05 ）. After treatment, Blood viscosity at high Shear Rates, Blood viscosity at middle Shear Rates, Blood vis- cosity at low Shear Rates, Hematocrit, Erythrocyte aggregation index levels of two groups were significantly decreased（ P 〈 0.05 ） , and each indicators of observation group were significantly lower than those of control group（ P 〈 0.05 ）. Conclu- sion Edaravone combined torasemide could effectively improve the oxidative stress,inflammatory reaction and hemorheo- logy of patients with acute cerebral hemorrhage and promote the circulation rate of blood microcirculation.