阿托伐他汀钙联合清脑通络方对缺血性脑血管病脑微出血患者血脂水平的影响

Effects of atorvastatin calcium and Qing Nao Tong Luo Fang on serum lipid level in patients with ischemic cerebrovascular intracerebral hemorrhage

目的探讨阿托伐他汀钙联合清脑通络方对缺血性脑血管病脑微出血患者临床疗效及血脂水平的影响。方法将78例缺血性脑血管病脑微出血患者采用随机数字表法分为观察组与对照组，各39例。两组均给予阿托伐他汀钙治疗，观察组联合清脑通络方治疗，观察90d。比较两组临床疗效、血脂水平、血流变学指标水平及不良反应发生情况。结果观察组总有效率显著高于对照组（P〈0．01）。治疗后观察组总胆固醇、甘油三酯及低密度脂蛋白水平均较治疗前显著降低（P〈0．01），且显著低于对照组（P〈0．01），高密度脂蛋白水平较治疗前显著升高（P〈0．01），且显著高于对照组（P〈0．01），对照组与治疗前比较差异无统计学意义（P〉0．05）。治疗后两组全血高粘度、血浆粘度及血小板粘附率水平均显著低于治疗前（P〈0．05或0．01），观察组全血高粘度水平较对照组下降更显著（P〈0．05）。两组不良反应发生情况比较差异无统计学意义（P〉0．05）。结论阿托伐他汀钙联合清脑通络方治疗缺血性脑血管病脑微出血患者疗效显著，可有效改善患者血脂水平，安全性高，值得临床推广应用。

Objective To study the effect of atorvastatin calcium and Qing Nao Tong Luo Fang on blood lipid level in patients with ischemic cerebrovascular intracerebral hemorrhage. Methods 78 patients with ischemic cerebrovascular intracerebral hemorrhage were selected and divided into observation group and control group according to digital random method, 39 cases in each group. The two groups were all given atorvastatin calcium treatment, observation group was plus Qing Nao Tong Luo Fang based on control group, they were observed for 90d. Clinic effect, blood lipid level, blood rheological indicators level and adverse reactions of the two groups were compared. Results Total efficiency of observation group was higher than control group （P〈0.01）. After treatment, total cholesterol, triglyceride, LDL level of obser- vation group were obviously declined （P〈0.01）, and obviously lower than control group （P〈0.01）, HDL was obviously increased compared with before treatment （P〈0.01） and obviously higher than control group （P〈0.01）, difference was not statistic significant in control group after treatment （P〈0.05）. After treatment, whole blood high viscosity, plasma viscosity, platelet adherence rate of the two groups were obviously lower than those before treatment （P〈0.05 or 0.01）, hole blood high viscosity level of observation group declined more obviously than control group （P〈0.05）. Difference of adverse reactions between the two groups had no statistic significance （P〉0. 05）. Conclusion Atorvastatin calcium and Qing Nao Tong Luo Fangin treating patients with ischemic cerebrovascular intracerebral hemorrhage has significant effect, it can improve blood lipid level, it has higher safety and is worthy of clinic promotion.