硝苯地平联合氢氯噻嗪治疗老年高血压效果及对肾功能的影响

Effect of nifedipine combined with hydrochlorothiazide in treating elderly hypertension and its influence on renal function

目的研究硝苯地平联合氢氯噻嗪治疗老年高血压的效果及对。肾功能的影响。方法将142例老年高血压患者抽签随机分为两组，每组71例。两组均予以硝苯地平治疗，观察组在此基础上联合氢氯噻嗪治疗，观察4个月。比较两组的临床疗效、血压变化、肾功能指标。结果观察组总有效率为88．7％，对照组为76．1％，观察组显著高于对照组（P〈0．05）。治疗后两组收缩压、舒张压和血肌酐、尿素氮、尿微量白蛋白水平均较治疗前显著降低（P〈0．01），观察组显著低于对照组（P〈0．01）。结论硝苯地平联合氢氯噻嗪治疗老年高血压可稳定而持久的控制血压，同时保护肾脏功能，对患者预后有重要作用。

Objective To investigate the effect of nifedipine combined with hydrochlorothiazide in treating elderly hypertension and its influence on renal function. Methods 142 ca ses with elderly hypertension were selected and divided into two groups according to stochastically ballot, 71 cases in each group. Patients were all given nifedipine treatment, observation group was plus hydro chlorothiazide treatment on this basis, they were observed for 4 months. Clinic effect, blood pressure changes, renal function indexes of the two groups were compared. Results Total efficiency of observation group （88.7%） was higher than control group （76.1%） （P〈0.05）. Systolic and diastolic pressure, serum creatinine, urea nitrogen, microalbuminuria level of the two groups after treatment were significantly declined （P〈0.01）, observation group was lower than control group （P〈0.01）. Conclusion Nifedipine combined with hydrochlorothiazide in treating elderly hypertension can control blood pressure steadily and unduringly, it can also protect renal function and play important role in patients＇ prognosis.