草酸艾司西酞普兰与米氮平治疗抑郁症对照研究

Comparison of clinical efficacy of escitalopram oxalate and mirtazapine in the treatment of depression

目的比较草酸艾司西酞普兰与米氮平治疗抑郁症的临床疗效及安全性。方法将80例抑郁症患者按随机数字表法分为两组，每组40例。艾司西酞普兰组予以草酸艾刊西酞普兰治疗，米氮平组予以米氮平治疗，观察8周。于治疗前后采用汉密顿抑郁量表判定临床疗效，副反应量表评定不良反应。结果艾司西酞普兰组总有效率为95．0％，米氮平组为92．5％，两组比较差异无统计学意义（P〉0．05）。治疗2周末起两组汉密顿抑郁量表评分较治疗前显著降低（P〈0．01），同期两组间比较差异尤统计学意义（P〉0．05）。两组不良反应比较差异无统计学意义（P〉0．05）。结论草酸艾司西酞普兰与米氮平治疗抑郁症疗效显著且相当，安全性较高。

Objective To compare the efficacy of escitalopram oxalate and mirtazapine in the treatment of depression. Methods 80 cases of depression patients were selected and divided into two groups according to random number table, 40 cases in each group. Escitalopram group was given treatment of escitaloprarn oxalate, mirtazapine group was given treatment of mirtazapine, patients were observed for 8 weeks. Clinic effect of the two groups before and after treatment was evaluated by HAMD, adverse reactions was evaluated by the TESS. Results Total efficiency of escitalopram group and mirtazapine group were 95. 0%, 92.5%, the difference between the two groups had no statistic significance （P〉0.05）. After treatment of 2 weeks, HAMD score of the two groups obviously declined （P〈0.01）, the difference between the two groups at the same term had no statistic significance （P〉0.05）. Conclusion Escitalopram oxalate and mirtazapine have same and significant effect in the treatment of depression, it also has higher safety.