氟西汀联合解郁通络汤治疗脑卒中后抑郁患者临床疗效

Clinic effect of fluoxetine and Jieyutongluotang on post-stroke depression patients

目的探讨氟西汀联合解郁通络汤治疗脑卒中后抑郁患者的临床疗效。方法将74例脑卒中后抑郁患者采用随机数字表法分为研究组与对照组各37例，两组均口服氟西汀，研究组联合解郁通络汤，观察12周。比较两组临床疗效，采用汉密顿抑郁量表以及抑郁自评量表评定患者的抑郁程度，美国国立卫生院神经功能缺损评分评定神经功能缺损情况，健康调查简表评定生活质量。结果研究组总有效率为97．3％，对照组为86．8％，研究组显著高于对照组（P〈0．05）。治疗后两组汉密顿抑郁量表、抑郁自评量表、美国国立卫生院神经功能缺损评分及抑郁自评量表严重指数均显著低于治疗前（P〈0．01），健康调查简表评分显著高于治疗前（P〈0．01），研究组较对照组变化更显著（P〈0．01）。结论氟西汀联合解郁通络汤治疗脑卒中后抑郁患者疗效显著，能有效改善患者抑郁程度、生活质量以及神经功能。

Objective To investigate the clinic effect of fluoxetine and Jieyutongluotang on post-stroke depression patients. Methods 74 post-stroke depression patients were selected and divided into two groups, 37 cases in each group, patients were all given oral fluoxetine, observation group was plus Jieyutongluotang, patients were observed for 12 weeks. Clinic effect of the two groups was compared, depression degree was evaluated by HAMD and SDS, neurologic impairment condition was evaluated by NIHSS, life quality was evaluated by SF-36. Results Total efficiency of observation group （97.3%） was higher than control group （86.8%） （P〈0. 05）. After treatment, scores of HAMD, SDS, NIHSS and SDS EASI of the two groups were all lower than those before treatment （P〈0.01）, SF-36 score was significantly higher than that before treatment （P〈0.01）, observation group changed more significantly than control group （P〈0.01）. Conclusion Fluoxetine and Jieyutongluotang have significant effect on post-stroke depression patients, it can improve depression degree, life quality and neurological function of patients.