咪达唑仑联合芬太尼在纤维支气管镜检查中的应用效果评价

Evaluation of the effects of midazolam combined with fentanyl in fiberoptic bronchoscopy

目的探讨咪达唑仑联合芬太尼在纤维支气管镜检查中的应用效果。方法将102例呼吸系统疾病及疑似待诊患者按随机数字表法分为观察组54例与对照组48例。两组均给予局部麻醉，观察组在此基础上采用咪达唑仑联合芬太尼麻醉方法进行纤维支气管镜检查。结果入声门时及检查中两组平均动脉压、心率均较麻醉前显著上升（P〈0．05），血氧饱和度显著下降（P〈0．05），对照组较观察组变化更显著（P〈0．05），检查中两组血氧饱和度变化比较差异无统计学意义（P〉0．05），检查后与麻醉前比较差异无统计学意义（P〉0．05）。结论将咪达唑仑联合芬太尼应用于纤维支气管镜检查中可以明显提高患者的舒适度和耐受性，不良反应小，值得临床推广应用。

Objective To explore the effects of midazolam combined with fentanyl in fiberoptic bronchos- copy. Methods one hundred and two respiratory disease and suspected patients were assigned to two groups according to random number table. Both groups received local anesthesia, and research group （n=54） did midazolam plus fentanyl treatment,too. Results When fiberoptic bronchoscope entered glottises and during the inspection progress, Mean arterial pressure and heart rate of 2 groups heightened more significantly compared with pre-anesthesia （P〈0.05）, and Oxygen saturation lowered（P〈0.05）and changes of control group were more significant than research （P〈0.05）. In terms of oxygen saturation, group differences weren＇t statistically significant during the inspection process （P〉0.05）, and between posttreatment and pre-anesthesia（P〉0.05）. Conclusion Application of midazolam combined with fentanyl in fiberoptic bronchoscopy can significantly improve the patient＇s comfort and tolerance, adverse reactions are small, worthy of clinical application