C反应蛋白和降钙素原检测在儿童原发性肾病综合征病情评估中的应用研究

The application of C-reactive protein and procalcitonin in children with primary nephrotic syndrome

目的:探讨C反应蛋白(CRP)和降钙素原(PCT)在儿童原发性肾病综合征(PNS)中的临床应用价值。方法:选取2009年12月至2014年12月承德医学院附属医院收治的PNS患儿92例作为研究对象,其中单纯型肾病65例(单纯组),肾炎型肾病27例(肾炎组),另选取同期健康体检的50例健康儿童作为对照组。应用免疫比浊法测定全血CRP水平,电化学发光法测定血清PCT水平。比较3组患儿CRP、PCT、尿素氮(BUN)、肌酐(Cr)水平。结果:单纯组CRP、PCT水平分别为(11.64±13.56)mg/L、(0.89±1.72)μg/L,肾炎组CRP、PCT水平分别为(21.81±20.31)mg/L、(1.56±1.19)μg/L;均高于对照组的CRP水平(3.43±2.29)mg/L和PCT水平(0.16±0.13)μg/L,差异均有统计学意义(均P<0.05)。单纯组CRP、PCT水平与BUN均呈正相关关系(r=0.252、0.243,均P<0.05)。结论:全血CRP和血清PCT可能参与了PNS疾病的过程,这两项指标的检测有助于PNS的诊断,并可作为病情监测的重要指标。

Objective：To study the clinical applications of C-reactive protein （CRP） and serum procalcitonin （PCT） in children with primary nephrotic syndrome （PNS）. Methods：Ninety-two children with PNS admit- ted in our hospital from December 2009 to December 2014 were enrolled in this study. Among them, 65 children with simplicity were enrolled in the simplicity group, and 27 children with nephritis were enrolled in the nephritis group. Meanwhile, 50 healthy children were selected into the control group. The CRP level was detected by immunoturbidimetry, and PCT level was detected by electrochemiluminescence. The lev- els of CRP, PCT, urea nitrogen （BUN）, and creatinine （Cr） among groups were compared. Results： The levels of CRP and PCT were （11.64±13.56） mg/L and （0.89±1.72） μg/L in the simplicity group, and （21.81±20.31） mg/L and （1.56±1.19）μg/L in the nephritis group. They both had significantly elevated compared to the levels of CRP and PCT in control group, which were （3.43±2.29） mg/L and （0.16±0.13） μg/L, respectively （P〈0.05）. In addition, the level of CRP in simplicity group was positively cor- related with BUN in PNS children before treatment （r=0. 252,P〈0.05）. The similar results of the level of PCT in simplicity group were observed （r=0. 243, P%0.05）. Conclusion.CRP and PCT were possible to take part in the development of PNS, which might contribute to the diagnosis of PNS. They could be used as the important markers in the monitoring of PNS.