内镜黏膜下剥离术治疗食管早期癌及癌前病变的临床分析

Clinical outcomes of endoscopic submucosal dissection for early esophageal cancers and precancerous lesions

目的:评价内镜黏膜下剥离术(ESD)治疗食管早期癌及癌前病变的临床效果及安全性。方法:46例食管早期癌及癌前病变的患者按治疗方法分为两组,23例接受ESD治疗的食管早期癌及癌前病变患者为治疗组,另23例接受内镜黏膜切除术(EMR)的患者作为对照组。比较两组患者的病灶大小、平均手术时间、病灶切除情况、术后并发症。结果:治疗组病灶平均直径、平均手术时间高于对照组(P<0.05);治疗组完整切除率及治愈性切除率高于对照组(P<0.05);治疗组与对照组术后并发症差异无统计学意义(P>0.05)。结论:ESD治疗食管早期癌及癌前病变安全有效,具有广阔的应用前景。

Objective： To evaluate the efficacy and safety of endoscopic submucosal dissection （ESD） for early esophageal cancer and precancerous lesions.Methods： Forty-six patients with early esophageal cancer and precancerous lesions were allocated to ESD group （n = 23 ） and EMR group（ controls, treated with endoscopic mucosal resection ,EMR ,n = 23）.Two groups were compared pertaining to the lesion size, average operative time, lesion resection and complications.Results： The lesion removed had larger average diameter and the operative time was longer in ESD group（P〈0.05） , and ESD group had higher complete resection and curative resection than EMR group（ P〈0.05 ） , yet the complications were not significantly different（ P〉0.05 ）.Conclusion： ESD is an effective method for treatment of early esophageal cancer and precancerous lesions, suggesting that it is promising in clinical application.