启膈散治疗反流性食管炎的效果及对细胞因子的影响

Effective Analysis of Using Qige Powder in the Treatment of Reflux Esophagitis and Its Effect on Cytokines

目的:观察启膈散治疗反流性食管炎的效果分析及对细胞因子的影响。方法:选取2016年1月~2016年6月我院消化科门诊及病房收治的92例反流性食管炎患者,根据随机数字表,将92例患者分为观察组(n=46)和对照组(n=46)。对照组奥美拉唑肠溶胶囊治疗,观察组采用启膈散联合奥美拉唑肠溶胶囊治疗。比较两组患者临床疗效、胃镜检查总积分、细胞因子、胃肠激素、不良反应发生率及复发率。结果:观察组的总有效率(91.3%)显著高于对照组(80.4%)(P<0.05)。治疗后观察组胃镜检查总积分显著低于对照组(P<0.05)。观察组P16阳性表达率及NO水平显著低于对照组(P<0.05)。观察组血清GAS、MTL水平显著高于对照组(P<0.05)。两组患者各不良反应发生率差异无显著性(P>0.05),观察组复发率显著低于对照组(P<0.05)。结论:启膈散联合奥美拉唑肠溶片治疗反流性食管炎的效果确切,可显著改善患者临床症状,提高胃肠激素水平,值得推广。

Objective：To investigate the effect of using Qige Powder in the treatment of reflux esophagitis and its effect on cytokines.Methods：92 patients with reflux esophagitis were selected from January 2016 to June 2016 in the department of gastroenterology outpatient and ward in our hospital.According to the random number table,92 patients were divided into observation group（n=46） and controlled group（n=46）.The controlled group was treated with Omeprazole Enteric-coated Capsule,the observation group was treated with Omeprazole Enteric-coated Capsule combined with Qige Powder.The clinical efficacy,total score of gastroscope,cytokines,gastrointestinal hormones,incidence of adverse reactions and recurrence rate were compared between the two groups.Results：The total effective rate of the observation group（91.3%） was significantly higher than that of the controlled group（80.4%）（P〈0.05）.After treatment,the total score of gastroscope in the observation group was significantly lower than that of the controlled group（P〈0.05）.The positive expression rates of P16 and NO level in the observation group were significantly lower than those in the controlled group（P〈0.05）.The levels of serum GAS and MTL in the observation group were significantly higher than those in the controlled group（P〈0.05）.There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）,the recurrence rate of the observation group was significantly lower than that of the controlled group（P〈0.05）.Conclusion：The effect of Qige Powder combined with Omeprazole Enteric-coated Tablets in the treatment of reflux esophagitis is accurate,can significantly improve the clinical symptoms and improve the level of gastrointestinal hormones,which is worthy of promotion.