益肾健脾汤联合西药治疗慢性尿酸性肾病的疗效及对其肾功能、氧化应激的影响

Effect of Using Yishen Jianpi Decoction Combined with Western Medicine in the Treatment of Chronic Uric Acid Nephropathy and the Impact on Renal Function and Oxidative Stress

目的:观察益肾健脾汤联合西药治疗慢性尿酸性肾病(CUNA)的疗效及对其肾功能、氧化应激产生的影响。方法:纳入2015年3月~2016年11月我院收治的82例CUNA病例作为研究对象,按照随机数字表法将其分为2组,各41例,对照组单纯予以西药治疗,观察组予以益肾健脾汤联合西药治疗,比较2组治疗前后肾功能、氧化应激指标及疗效。结果:观察组治疗总有效率为90.24%,明显高于对照组73.17%(P<0.05);观察组肾病指数(136.28±17.59)、Scr(91.03±7.57)μmol/L、UAER(104.84±13.22)μmol/L、BUA(291.61±25.37)mg/24小时明显低于对照组(166.33±21.37)、(97.84±9.52)μmol/L、(137.51±30.64)μmol/L、(316.62±32.58)mg/24小时(P<0.05);观察组AOPP(38.23±4.52)μmol/L、MDA(3.32±0.38)nmol/L、T-AOC(17.82±1.83)U/m L明显低于对照组(31.76±4.35)μmol/L、(5.48±0.52)nmol/L、(15.22±1.48)U/ml,且SOD(89.55±9.08)U/ml明显高于对照组(84.61±8.37)U/ml(P<0.05)。结论:对CUNA患者实施益肾健脾汤联合西药治疗方案,可显著改善氧化应激相关指标,提高肾脏功能,疗效确切,具有积极推广意义。

Objective：To study the efficacy of Yishen Jianpi Decoction combined with western medicine in the treatment of chronic uric acid nephropathy（CUAN）and the effect on renal function and oxidative stress.Methods：A total of 82cases with CUAN admitted to our hospital from March 2015to November 2016were selected as the study subjects and were divided into two groups by the random number table method,41cases in each group.The control group were treated with western medicine alone while the observation group were treated with Yishen Jianpi Decoction combined with western medicine.The renal function,oxidative stress indexes and efficacy were compared between the two groups.Results：The total effective rate of treatment was significantly higher in the observation group than the control group（90.24%vs 73.17%）（P〈0.05）.The nephropathy index,Scr,UAER and BUA in the observation group[（136.28±17.59）,（91.03±7.57）μmol/L,（104.84±13.22）μmol/L,（291.61±25.37）mg/24h]were significantly lower than those in the control group[（166.33±21.37）,（97.84±9.52）μmol/L,（137.51±30.64）μmol/L,（316.62±32.58）mg/24h]（P〈0.05）.AOPP,MDA and T-AOC in the observation group[（38.23±4.52）μmol/L,（3.32±0.38）nmol/L,（17.82±1.83）U/ml]were significantly lower than those in the control group[（31.76±4.35）μmol/L,（5.48±0.52）nmol/L,（15.22±1.48）U/ml]while SOD（89.55±9.08）U/ml was significantly higher than that in the controlled group（84.61±8.37）U/ml（P〈0.05）.Conclusion：The treatment of patients with CUAN with Yishen Jianpi Decoction combined with western medicine can significantly improve the oxidative stress related indicators and improve renal function.