清胃汤联合头孢拉定对牙周病患者血清TNF-α及临床疗效的影响

Curative Effect and Serum TNF Alpha Level of Cefradine and Qingwei Decoction for Treating Periodontosis

目的:观察头孢拉定联合清胃汤对牙周病患者血清TNF-α及临床疗效的影响。方法:选择2016年1月至2016年3月在我院接受治疗的120例牙周病患者,根据给予患者不同治疗方法分为观察组和对照组,对照组用头孢拉定进行治疗,观察组则联合清胃汤进行治疗,均治疗2周,观察其治疗后的疗效以及对血清TNF-α的影响。结果:治疗后,观察组总有效率为95.0%,明显高于对照组(83.3%),两组比较差异具体统计学意义(P<0.05);治疗后,观察组血清TNF-α水平为(6.97±1.54)ng/L,明显低于对照组(7.58±1.59)ng/L,两组比较差异显著(P<0.05);观察组牙龈指数、牙龈沟出血指数、菌斑指数以及探针深度均明显低于对照组(P<0.05)。两组均发生了一些并发症,观察组发生率明显低于对照组(P<0.05)。结论:使用头孢拉定联合清胃汤治疗牙周病患者,能够明显降低血清TNF-α水平,其临床疗效显著,并能够降低并发症发生率,安全性较好。

Objective：To study the curative efficacy of Cefradine and Qingwei Decoction in the treatment of periodontosis and its effect on serum TNF alpha.Methods：120 patients of periodontosis who received therapy from January 2016 to March 2016 in our hospital were selected as research objects,and in accordance with the method of the treatment would be divided into observation group and controlled group,the controlled group used cephalosporins set for treatment,the observation group combined with Qingwei Decoction for treatment,treated for 2weeks,observed the efficacy of treatment and the effect of serum TNF alpha.Results：After treatment,the total effective rate of the observation group was 95.0%,significantly higher than that of the controlled group,the total effective rate was 83.3%,specific statistical significance difference comparing the two groups（P〈0.05）;After treatment,the observation group of serum TNF alpha level for（6.97 ± 1.54） ng/L,significantly lower than that of the controlled group（7.58±1.59） ng/L,the two groups was significant difference（P〈0.05）;And the observation group of gingival index,gingival sulcus bleeding index,plaque index and probe depth were significantly lower than the controlled group（P〈0.05）,after treatment,the two groups had happened a series of complications,the incidence rate of the observation group was significantly lower than that of the controlled group（P〈0.05）.Conclusion：Using Cephalosporins,fixed joint Qingwei Decoction in the treatment of periodontal disease patients,can significantly lower the serum level of TNF alpha,the clinical curative effect is distinct,and can reduce the incidence of complications and better security.