肺腺癌术后早期复发的影响因素分析

Influence factor analysis for early relapse of postoperative lung adenocarcinoma

目的分析肺腺癌术后早期复发的影响因素。方法回顾性分析行手术治疗的72例肺腺癌患者临床资料,通过单因素分析及多因素Logistic回归分析探究影响术后肺腺癌早期复发的因素。结果 72例肺腺癌患者中,24例肺癌早期复发。单因素分析结果显示,肺癌早期复发情况在患者的年龄(χ~2=5.548,P=0.028)、肿瘤最大径(χ~2=7.141,P=0.008)和术前癌胚抗原(carcino-embryonic antigen,CEA)水平(χ~2=6.063,P=0.014)方面差异均具有统计学意义。多因素Logistic回归分析显示,肿瘤最大径是影响肺癌早期复发的独立危险因素(P=0.042)。结论肿瘤最大径是影响肺腺癌术后早期复发的重要因素。

Objective To analyze the factors influencing the early relapse of lung adenocarcinoma after surgical resection. Methods Clinical data of 72 cases of lung adenocarcinoma patients who underwent surgical treatment were retrospectively analyzed. Univariate analysis and multivariate logistic regression analyses were applied to explore the influence factors associated with early relapse of postoperative lung adenocarcinoma. Results Among the 72 lung adenocarcinoma patients,24 patients relapsed after surgery. Univariate analyses indicated that patients＇ age（ χ~2= 5. 548,P = 0. 028）,maximum tumor diameter（ χ~2= 7. 141,P = 0. 008） and preoperative carcino-embryonic antigen（ CEA） level（ χ~2= 6. 063,P =0. 014） were significantly associated with postoperative early relapse. Multivariate logistic regression analysis identified maximum tumor diameter as an independent risk factor of early relapse（ P = 0. 042）. Conclusion Maximum tumor diameter is a significant influence factor of early relapse in postoperative lung adenocarcinoma patients.