高强度间歇运动对糖尿病前期患者糖脂代谢的影响

Effects of high intensity-interval training on glucolipid metabolism in a pre-diabetic population

目的:探讨高强度间歇运动(high intensity-interval training,HIIT)对糖尿病前期(prediabetes mellitus,PDM)患者糖脂代谢的影响。方法:选取PDM患者60例,按照随机数表法将其分为高强度间歇运动组(HIIT组)、中等强度持续运动组(MICT组)、空白对照组(对照组),每组20例。HIIT组采用60s高强度运动(70%—90%最大心率)搭配60s间歇的训练方式,每次20min,每周3次,共12周。MICT组采用中等强度(50%—70%最大心率)的持续运动,每次50min,每周3次,共12周。对照组设置为空白对照组,不予以其他运动干预。12周干预前、后,分别测量各组空腹血糖、餐后2h血糖、糖化血红蛋白(Hb Alc)、血脂、体重指数(BMI)、腰围数据。结果:研究结束前,MICT组有两例患者因无法坚持退出研究。训练前,3组患者各组数据之间比较,差异均无显著性意义(P≥0.05)。12周干预后,HIIT组与运动前及同期对照组相比,腰围、空腹血糖、餐后2h血糖、Hb Alc水平、总胆固醇及甘油三酯水平降低(P<0.05),高密度脂蛋白水平升高(P<0.05)。MICT组与训练前及同期对照组比较,腰围、空腹血糖、餐后2h血糖、总胆固醇和甘油三酯水平降低(P<0.05)。与训练前相比,对照组3个月后腰围、空腹血糖、餐后2h血糖、Hb Alc、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白等数据均无明显变化(P≥0.05)。与MICT组相比,HIIT组腰围减少更显著(P<0.05)。结论:高强度间歇运动可以有效改善糖尿病前期患者空腹血糖和餐后2h血糖情况且减脂效果较传统中等强度持续运动更佳。

Objective： To evaluate the effect of high intensity-interval training on glucolipid metabolism in pre-diabetic population. Method： Sixty patients with PDM were randomly divided into high intensity-interval training （HIIT） group, medium intensity continues training （MICT） group and control group, 20 members in each. The HIlT group took 60s high intensity exercise （70%--90% HRmax） and 60s resting followed, 10 times repeated in one ses- sion, 3 sessions a week for 12 weeks. The MICT group took medium intensity （50%--70% HRmax） exercise continuously, for 50min in one session, 3 sessions a week for 12 weeks. There was no exercise intervention for control group. Before and after 12 weeks intervention, fast blood glucose （FBG）, 2 hours postprandial blood glucose （PBG）, HbAlc, and lipid profile were tested. Body mass index （BMI） and waist circumference （WC） were also measured. Result： Before the intervention, there were no significant differences in any of the average value among the 3 groups. Two patients in MICT group dropped out before the study end. In HIIT group, the average value of FBS, PBG, HbAlc, total cholesterol （TC）, TG and WC all decreased significantly after training, and HDL in- creased significantly after training （P〈0.05）. In MICT group, the average value of FBS, PBG, TC, TG and WC decreased significantly after training（P〈0.05）. There were no significant differences in control group 12 weeks lat- er（P~〉0.05）. Moreover, compared with MICT group, patients in HIIT group had more decrease in WC （P〈0.05）. Conclusion： HIIT is effective exercise prescription for PDM patients for controling their glucolipid metabolism. Comparing with traditional MICT, HIIT had significant advantage in decreasing WC.