口服补充维生素D_3对血压影响的荟萃分析

Effects of vitamin D_3 supplement on blood pressure:a meta-analysis

目的通过荟萃分析了解补充维生素D_3对血压的影响。方法计算机检索中国生物医学文献数据库(1978-2015)、中国知网(1979-2015)、万方数据库(1982-2015)、维普中文科技期刊数据库(1989-2015)、PubMed(1980-2015)、Science Direct(1980-2015)、Medline(1972-2015)、SpringerLink(1980-2015)、Embase(1974-2015)、The Cochrane Library(1992-2015)数据库中有关原发性高血压患者及正常血压人群口服补充维生素D_3后血压水平变化的临床随机对照试验,由2位评价者根据纳入标准独立筛选文献、提取资料并评价质量。运用RevMan5.3软件对符合条件的所有结果进行荟萃分析。结果最终纳入9篇随机对照研究,共1052名研究对象,采用改良Jadad评分评价纳入研究的方法学质量,5篇7分,1篇6分,2篇5分,1篇3分。荟萃分析结果显示:与安慰剂组相比,口服补充维生素D_3可降低原发性高血压患者收缩压及舒张压水平,但不影响正常血压人群的血压水平。结论补充维生素D_3可降低原发性高血压患者血压水平,但对正常血压人群的血压水平无明显影响。

Objective This study performed a systematic review to evaluate the impact of vitamin D3 supplement on blood pressure, so as to provide a basis for clinical treatment. Methods Such database as The CBM （ 1978-- 2015）, CNKI（1979--2015）, Wanfang （1982--2015）, VIP（1989--2015）, PubMed（1980--2015）, Science Direct （ 1980 -- 2015 ）, Medline（ 1972 -- 2015 ）, SpringerLink （ 1980 -- 2015 ）, Embase （ 1974 -- 2015 ） and The Cochrane Library（1992--2015） were searched to collect the randomized controlled trials （RCT） about the impact of oral vitamin D3 supplement on blood pressure in hypertensive and normotensive population. Two reviewers screened independ ently the literature according to the inclusion criteria, extracted the data and assessed the quality. Then the meta analysis was performed using RevMan 5.3 software. Results A total of 9 studies involving 1052 participants were included. The methodological quality based on the improved Jadad scales displayed that 5 studies scored 7, 1 study scored 6,2 studies scored 5 and only 1 study scored 3. The results of meta-analysis showed that compared with the placebo groups, oral vitamin D3 supplement reduced both systolic and diastolic blood pressure in hypertension pa- tients but had no effect on normotensive population. Conclusion Compared with placebo, oral vitamin D3 supplement has impact on both systolic and diastolic blood pressure in hypertensives but has no effect on normotensive population.