122例清开灵注射剂致严重不良反应报告分析

Analysis of 122 Serious ADR Cases Induced by Qingkailing Injection

目的:分析清开灵注射剂致严重不良反应发生规律,为临床安全合理用药提供参考。方法:采用回顾性研究方法,对贵州省黔南州的122例清开灵注射剂致严重不良反应报告表进行综合分析。结果:女性略高于男性其中男性占46.72%,女性占53.28%;多数严重不良反应发生在用药后30min内,占73.77%;临床表现以呼吸系统损害最常见,占26.45%,其次为全身性损害,占21.80%和中枢及外周神经系统损害,占15.99%。结论:临床应用清开灵注射剂时应密切观察30min内患者的情况,尽量减少和避免不良反应的发生。

Objective To explore the general rule of serious adverse drug reaction （ADR） induced by Qingkailing injection. Methods 122 serious ADR cases of Qingkailing of injection reported in Qiannan of Guizhou province were collected and satistieally ana- lyzed. Results The number of female slightly was higher than male, male 46. 72%, female 53.28% ; Most serious adverse events oc- curred within 30 minutes, 73.77%; Respiratory damage was one of the most common, 26.45%, followed by systemic damage, 21.80% and the central and peripheral nervous system damage （ 15.99% ）. Conclusion To reduce and avoid the occurrence of ad- verse reactions as far as possible, Qingkailing injection should be closely observed patients within 30 minutes.