经导管主动脉瓣置换术的研究进展

Research status and progress of transcatheter aortic valve implamtation

主动脉瓣狭窄(AS)是老年人最常见的瓣膜退行性改变,发病率正逐年上升。经导管主动脉瓣置换术(TAVR)的临床应用为AS患者提供了一种全新的治疗方法,目前TAVR已经成为不能进行外科手术或具有高外科手术风险的重度AS患者的有效替代治疗方案。欧美国家开展的TAVR注册研究进一步肯定了TAVR的效果。近期一些重要的随机对照临床试验及注册研究结果已经报道,现将近期重要的试验结果作一综述。

Aortic stenosis （AS） is the most common degenerative valvular disease in the elderly, and its incidence is increasing annual-ly. Transcatheter aortic valve replacement （TAVR） is a feasibly alternative treatment for patients with severe aortic stenosis and prohib- itive/high operative risk. TAVR registry studies carried out in Europe and the united states further affirm the effectiveness of TAVR. Re-cently, some randomized controlled clinical trials and registry studies have been reported. This paper aims to review the results of impor-tant trials and registries.