轻度亚临床甲状腺功能减退对2型糖尿病患者颈动脉内膜厚度的影响

Effect of mild subclinical hypothyroidism on carotid intima media thickness in patients with type 2 diabetes

目的探讨轻度亚临床甲状腺功能减退对2型糖尿病患者血脂、血尿酸、颈动脉内膜厚度(CIMT)的影响。方法选择2型糖尿病患者105例,根据促甲状腺激素(TSH)结果分成轻度亚临床甲状腺功能减退组(观察组,50例)和非甲状腺功能减退组(对照组,55例),比较两组血脂谱、血尿酸及颈动脉内膜厚度等指标。结果两组间年龄、血压、体质量指数比较差异无统计学意义,血脂谱、血尿酸及颈动脉内膜厚度比较差异有统计学意义(P<0.05)。Pearson单因素相关分析,患者的糖尿病病程、糖化血红蛋白、TSH、血尿酸、血肌酐与颈动脉内膜厚度存在相关性(P<0.05)。多因素相关分析,TSH、尿酸与颈动脉内膜厚度密切相关(P<0.05)。结论 TSH升高是2型糖尿病患者动脉粥样硬化的独立危险因素。

Objective To explore the effect of mild subclinical hypothyroidism on blood lipid, blood uric acid, carotid intima media thickness （ CIMT） in patients with type 2 diabetes mellitus （T2DM） . Methods We chose 105 cases of type 2 diabetes mellitus and assigned them into two groups according to the results of the TSH,mild subclinical hypothyroidism group （observation group,50 cases） and non-subclinical hypothyroidism group （ control group, 55 cases）. Blood lipid spectrum, blood uric acid and carotid intima media thickness were compared between the two groups. Results Age, blood pressure and body mass index between the two groups were notsignificantly different. Compared with control group,blood lipid spectrum,blood uric acid and carotid intima media thickness had signifi-cant differences in observation group （P 〈 0. 05 ）. Pearson single-factor correlation analysis indicated that the patients, course of dis-ease, glycosylated hemoglobin, TSH, blood uric acid, and creatinine were correlated with CIMT. Multifactorial analysis indicated that TSH and blood uric acid were closely related to CIMT. Conclusions An increased TSH in T2DM patients is an independent risk fac-tor for atherosclerosis.