阿托伐他汀对脑梗死患者外周血炎性因子的作用

The Effect of Atorvastatin on Cerebral Infarction in Patients with Peripheral Blood Inflammatory Factors

目的分析阿托伐他汀对脑梗死患者外周血炎性因子的作用。方法整群选择2014年3月—2015年11月该院治疗的病因分型为动脉粥样硬化型的急性脑梗死患者205例,所有患者在发病后立即治疗,治疗后3 d抽取静脉血,用酶联免疫吸附法检测血清中细胞因子IFN-γ、IL-2、IL-10、IL-17及血脂。比较两组内及两组间治疗前、治疗后细胞因子、血脂的变化情况。结果实验组治疗前IL-17、IL-2、IFN-γ、IL-10所测数据分别为(117.1±19.3)、(85.3±21.1)、(138.5±23.1)、(12.8±3.5)ng/L,治疗后所测数据为(78.6±13.6)、(49.8±17.2)、(98.3±16.3)、(20.7±4.1)ng/L,IL-10治疗后所测数值水平升高,治疗前相比差异有统计学意义(P<0.05);实验组患者治疗前后(Th17、Treg、Th17/Treg)分别为[(1.84±0.46)%、(2.14±0.80)%、(0.87±0.39)]、[(1.24±0.31)%、(3.25±0.54)%、(0.35±0.15)],比较差异有统计学意义(P<0.05)。结论阿托伐他汀能显著降低脑梗死患者Th1、Th17细胞分泌的细胞因子IFN-γ、IL-2、IL-17的水平,升高细胞因子IL-10以及纠正Th17/Treg失衡。

Objective Analysis of the effect of atorvastatin on cerebral infarction in patients with peripheral blood inflammatory factors. Methods 205 cases of patients with acute cerebral infarction treated in our hospital from March 2014 to November 2015 were group selected and the venous blood was extracted immediately after onset and in 3d after treatment,and the serum cytokine IFN-γ, IL-2, IL-10, IL-17 and blood liquid were tested by the enzyme-linked immunosorbent assay, and the cell factors and changes of blood liquid before and after treatment were compared between the two groups. Results The IL-17,IL-2,IFN-γ,IL-10 in the experimental group before treatment and after treatment were respectively（117.1±19.3）,（85.3±21.1）,（138.5±23.1）,（12.8±3.5）ng/L and（78.6±13.6）,（49.8±17.2）,（98.3±16.3）,（20.7±4.1）ng/L, and the differences were statistically significant（P〈0.05）, and the Th17,Treg,Th17/Treg in the experimental group before and after treatment were respectively[（1.84±0.46）%,（2.14±0.80）%,（0.87±0.39）vs（1.24±0.31）%,（3.25±0.54）%,（0.35±0.15）, and the differences were statistically significant（P〈0.05）. Conclusion The atorvastatin can obviously reduce the cell factor IFN-γ,IL-2,IL-17 levels secreted by Th1 and Th17 cells, increase cell factor IL-10 and correct the imbalance of Th17/Treg.