艾滋病抗病毒药物治疗的临床疗效及其不良反应研究

Research on Clinical Curative Effect and Adverse Reactions of Antiviral Drugs in Treatment of AIDS

目的探讨不同抗病毒药物方案治疗艾滋病的临床疗效及不良反应。方法方便选取120例艾滋病患者,均为2013年1月—2015年10月间收治,并随机分为研究1组、研究2组,应用含替诺福韦方案对研究1组患者实施治疗,应用含齐多夫定方案对研究两组患者实施治疗,比较两组患者治疗12个月后的CD4+T淋巴细胞计数及不良反应发生率。结果研究1组CD4+T淋巴细胞计数≥300个/μL的占60.3%%,研究2组占38.7%,研究1组CD4+T淋巴细胞计数上升幅度大于研究2组,差异有统计学意义(P<0.05)。研究1组不良反应发生4例(6.8%),研究2组不良反应发生12例(19.3%),研究2组不良反应发生率高于研究1组,差异有统计学意义(P<0.05)。结论含替诺福韦方案治疗艾滋病的疗效更可靠,不良反应更少,更具临床推广应用价值。

Objective To observe the clinical curative effect and adverse reactions of antiviral drugs in treatment of AIDS.Methods 120 cases of AIDS patients admitted and treated in our hospital from January 2013 to October 2015 were convenient selected and randomly divided into two groups, the research 1 group and research 2 group were treated with tenofovir and zidovudine, and the CD4＋T lymphocyte count and incidence rate of adverse reactions after 12 months were compared between the two groups. Results The CD4 ＋T lymphocyte count ≥300 μL in the research 1 group and in the research 2 group was respectively 60.3% and 38.7%, and the increase range of CD4＋T lymphocyte count in the research 1 group was bigger than that in the research 2 group, and the difference was statistically significant（P〈0.05）, and the incidence rate of adverse reactions in the research 2 group was higher than that in the research 1 group（12 cases vs 4 cases, 19.3% vs 6.8%）,and the difference was statistically significant（P〈0.05）. Conclusion The curative effect of tenofovir in treatment of AIDS is more reliable with fewer adverse reactions, and it is worth clinical promotion and application.