乳腺富于脂质癌的临床病例特点

Clinical Features of Lipid-rich Carcinoma of Breast

目的:探讨乳腺富于脂质癌临床特点。方法:对我院12例女性术后病理确诊为乳腺富于脂质癌患者的病理标本染色后用JEM-1011透射电镜观察。结果:90%的肿瘤细胞胞浆内可见大量空泡,内含中性脂肪。包浆中的脂肪含量越高,组织学恶性程度越高。分为四型:luminal A、luminal B、HER2过表达和三阴性。HER2过表达和三阴性两个类型的患者较其它类型乳腺癌患者的无瘤生存期显著缩短,几乎所有的基底细胞样乳腺癌均预后较差。结论:乳腺富于脂质癌可分为四型,预后较差。

Objective：To investigate the clinical characteristics of breast lipid-rich carcinoma Methods：The pathological specimens of 12 cases of breast lipid bearing carcinoma diagnosed by pathology in our hospital were observed with JEM-1011 transmission electron microscope after dyeing.Results：A large number of vacuoles were found in the cytoplasm of 90%tumor cells,containing neutral lipids.It is higher in fat content,histological malignant degree is higher.They were divided into four types：luminal,A,luminal,B,HER2,overexpression,and three negative.HER2 overexpression and three negative patients significantly shortened the disease-free survival of two types of breast cancer compared with other types of breast cancer,and almost all basal cell like breast cancers had a poor prognosis.Conclusion：Breast lipid-rich carcinoma can be divided into four types with poor prognosis.