脑心通胶囊对脑梗塞患者合并高血脂的血液流变学的影响

Effect of Naoxintong Capsule on Hemorrheology in Patients with Cerebral Infarction Complicated with Hyperlipidemia

目的:探讨脑心通胶囊联合阿托伐他汀对老年脑梗塞合并高血脂的血液流变学的影响。方法:138例脑梗塞合并高血脂的患者随机分为研究组(72例)和对照组(66例)。两组均给予阿托伐他汀治疗,研究组再加用脑心通胶囊治疗,30d为1个疗程。比较两组治疗前及治疗60d后的血脂及血流动力学情况。结果:治疗60d后,全血高切黏度、全血低切黏度、TC及TG水平,两组均较治疗前明显下降(P<0.05),研究组全血高切黏度、全血低切黏度及TC的下降幅度明显大于对照组(P<0.05);两组NIHSS评分均显著下降,研究组下降更明显;两组Brathel指数均显著提高,研究组提高幅度更明显(P<0.05)。研究组治疗的总有效率显著高于对照组,P<0.01。结论:脑心通胶囊联合阿托伐他汀能够显著改善脑梗塞患者血液黏度及日常生活活动能力,提高临床疗效。

Objective：To investigate the effect of Naoxintong capsule combined with atorvastatin on Hemorheology in elderly patients with cerebral infarction complicated with hyperlipidemia.Methods：138 patients with cerebral infarction complicated with hyperlipidemia were randomly divided into the study group（72 cases） and the control group（66 cases）.The two groups were treated with atorvastatin,and the study group was treated with Naoxintong capsule,and 30 d was treated for 1 courses.The blood lipid and hemodynamics of the two groups before and after treatment with 60 d were compared.Results：After 60 d treatment,whole blood viscosity,whole blood low shear viscosity,TC and TG,the two groups were significantly decreased compared with before treatment（P〈0.05）,the study group whole blood viscosity,whole blood low shear viscosity and TC decreased significantly greater than the control group（P〈0.05）;group NIHSS scores were two the study group decreased significantly,decreased significantly;Brathel index of two groups were significantly improved,study group increased more significantly（P〈0.05）.The total effective rate of the treatment group was significantly higher than that of the control group,P〈0.01.Conclusion：Naoxintong capsule combined with atorvastatin can significantly improve the blood viscosity and activities of daily living in patients with cerebral infarction,and improve the clinical efficacy.