血清IL-6与PCT在新生儿肺炎早期诊断中的检测意义

Detection of Serum Interleukin-6 and Procalcitonin in Early Diagnosis of Neonatal Pneumonia

目的:探析新生儿肺炎(NP)患儿的早期诊治中血清白细胞介素6(IL-6)与降钙素原(PCT)的临床检测意义。方法:分析82例NP患儿的临床资料,列为观察组(A组),按细菌感染情况将A组分成A1组(细菌感染性肺炎,45例)和A2组(非细菌感染性肺炎,37例)。另选同期体检的44例正常体检新生儿为对照组(B组)。比较各组的基线资料及治疗前后血清IL-6与PC%的表达水平。分析血清IL-6与PCT对NP患儿的诊断价值。结果:A组与B组儿童的基线资料无显著差异性(P>0.05)。A1组的血清IL-6与PCT水平显著较A2组、B组高(P<0.01)。A1患儿治疗前的血清IL-6与PCT水平显著较治疗后高(P<0.01)。血清IL-6与PCT对NP患儿的诊断价值各不相同。结论:血清IL-6与PCT在NP患儿的早期诊断中具有重要的临床检测意义。

Objective;To investigate the clinical significance of serum interleukin 6（IL-6） and procalcitonin（PCT） in the early diagnosis and treatment of neonatal pneumonia（NP）.Methods：The clinical data of 82 cases of NP,as the observation group（group A）,according to the situation of bacterial infection of A were divided into Al group（bacteria]pneumonia,45 cases） and group A2（non bacterial pneumonia,37 cases）.44 normal neonates were selected as control group（B group）.The baseline data and the levels of serum IL-6 and PCT were compared before and after treatment.Diagnostic value of serum IL-6 and PCT in children with NP.Results：There was no significant difference in baseline data between the A group and the B group（P〉0.05）.The serum IL-6 and PCT levels in group Al were significantly higher than those in A2 group and B group（P〈0.01）.The levels of serum IL-6 and PCT in children with Al were significantly higher than those before treatment（P〈0.01）.The diagnostic value of serum IL-6 and PCT in children with NP is different.Conclusion：Serum IL-6 and PCT have important clinical significance in early diagnosis of NP.