摘要
1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)是细胞膜鞘磷脂代谢过程产生的一类信号分子,在免疫系统中,与细胞膜表面的G蛋白偶联受体S1P受体(S1P receptors,S1PRs)结合,通过相关炎症信号通路,影响新生血管的形成。该文简述S1P及其受体通过细胞内信号转导对类风湿关节炎、多发性硬化症、结肠炎、系统性红斑狼疮等自身免疫性疾病微血管生成的影响,提出了S1P及其受体可能是治疗自身免疫性疾病血管炎症新的靶点。
Sphingosine-1-phosphate( S1P) is an important bioactive lipid produced from cell membrane sphingomyelin metabolism process. S1P and cell membrane surface S1P receptors( S1PR1-5) are G protein coupled receptors( GPCRs),which influence the formation of new blood vessels in the immune system via combining the related inflammatory signaling pathway.This review describes briefly the effects of S1P and S1PRs on autoimmune disease angiogenesis through intracellular signal transduction,such as rheumatoid arthritis,multiple sclerosis,colitis,systemic lupus erythematosus. Further research will be a new therapeutic target on vascular inflammation of autoimmune diseases.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2017年第9期1190-1194,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81473400)
安徽中医药大学探索性研究性项目(No 2016ts072)