重金属暴露与乳腺癌发病的关系初探

Study on relationship between heavy metals exposure and breast cancer

收集2012—2014年浙江省人民医院经病理确诊的新发女性原发性乳腺癌病例96例(病例组),以所在医院同期住院的乳腺良性疾病女性30例作为对照(对照组),采用ICP-MS检测血清和乳腺组织中重金属(镉、汞、砷、铬、铅)的含量。结果显示,病例组血清中镉、铬、砷和铅的检出水平显著(P<0.05)高于对照组,且组织样品中镉、铬、砷和铅的含量亦高于对照组。Logistic回归分析显示,血清中镉、铬、砷和铅的含量与乳腺癌发病发生存在关联,OR(比值比)值分别为12.364(95%置信区间:3.405~44.889)、132(95%置信区间:14.257~1 222.1)、4.941(95%置信区间:1.521~16.047)和7.416(95%置信区间:0.326~9.980),表明环境中镉、铬、砷和铅的暴露与女性乳腺癌的发生可能有一定关联。

To explore the relationship between heavy metals exposure and breast cancer,96 newly diagnosed cases of breast cancer（cancer group） and 30 matched normal cases（control group） were adopted as study materials,and the contents of heavy metals（Cd,Hg,As,Cr,Pb） in serum and breast tissues were determined by inductively coupled plasma mass spectrometry（ICP-MS）.It was shown that Cd,Cr,As and Pb contents in serum and breast tissues in the cancer group were significantly（P〈0.05） higher than those in the control group.Logistic regression analysis showed that Cd,Cr,As and Pb contents in the serum were associated with breast cancer risk.ORs of Cd,Cr,As and Pb were 12.364（95% CI：3.405-44.889）,132（95% CI：14.257-1 222.1）,4.941（95% CI：1.521-16.047） and 7.416（95% CI：0.326-9.980）,respectively,indicating that exposure to environmental heavy metals such as Cd,Cr,As and Pb may be one of the risk factors for breast cancer.