幽门螺杆菌感染对肠易激综合征及分型的影响

Impact of Helicobacter pylori infection on irritable bowel syndrome and its typing

目的探讨幽门螺杆菌感染对肠易激综合征及其分型的影响作用,为临床治疗提供参考依据。方法选择2013年1月-2015年12月浙江省荣军医院消化内科胃十二指肠疾病患者189例,将其分为观察组(幽门螺杆菌阳性组)135例和对照组(幽门螺杆菌阴性组)54例;比较观察组和对照组患者肠易激综合征的发病率及不同分型肠易激综合征的发病率,观察幽门螺杆菌根除对肠易激综合征症状的影响。结果观察组肠易激综合征的发病率为40.7%,显著高于对照组24.1%(P<0.05);观察组腹泻型、便秘型、混合型、不定型肠易激综合征的发病率与对照组比较,差异均无统计学意义;幽门螺杆菌根除成功组肠易激综合征的症状缓解率为76.9%,高于失败组43.8%(P<0.05)。结论幽门螺杆菌感染增加肠易激综合征的发病率,对肠易激综合征的分型无影响,幽门螺杆菌根除治疗可以提高肠易激综合征的症状缓解率。

OBJECTIVE To explore the impact of Helicobacter pylori infection on irritable bowel syndrome and its typing,so as to provide references for clinical treatment.METHODS A total of 189 cases of patients with gastroduodenal diseases of gastroenterology in our hospital from Jan.2013 to Dec.2015 were selected,which were divided into observation group（H.pylori positive group）with 135 cases and control group（H.pylori negative group）with 54 cases.The incidences of irritable bowel syndrome and different types of irritable bowel syndrome between observation group and control group were compared,and the effects of eradication of H.pylori on the symptoms of irritable bowel syndrome were observed.RESULTS The incidence of irritable bowel syndrome in observation group was 40.7%,which was significantly higher than 24.1%in control group（P〈0.05）.The incidence of diarrhea,constipation,hybrid,unstable irritable bowel syndrome between observation group and control group had no significant difference.The irritable bowel syndrome remission rate of H.pylori eradication success group was 76.9%,which was higher than 43.8% of failure group（P〈0.05）.CONCLUSION H.pyloriinfection increases the incidence of irritable bowel syndrome,and there is no effect on irritable bowel syndrome typing.H.pylori eradication therapy can increase the symptom relief rate of irritable bowel syndrome.