替考拉宁在胰十二指肠切除术后腹腔革兰阳性菌感染的疗效观察

Efficacy of teicoplanin in treatment of abdominal infections caused by gram-positive bacteria after pancreaticoduodenectomy

目的观察替考拉宁对行胰十二指肠切除术后革兰阳性菌所致腹腔感染中的疗效及安全性。方法选取2013年12月-2016年12月68例胰十二指肠切除术后腹腔感染患者,随机将其分为观察组和对照组,各34例,观察组应用替考拉宁治疗,对照组应用万古霉素治疗,比较两组患者应用不同抗菌药物的临床疗效和不良反应。结果替考拉宁与万古霉素治疗胰十二指肠切除术后腹腔感染治疗总有效率分别为88.24%及94.12%,两组比较差异无统计学意义;不良反应发生率分别为8.82%及29.41%,两组比较差异有统计学意义(P<0.05)。结论对于胰十二指肠切除术后革兰阳性球菌腹腔感染患者,应用替考拉宁敏感性较高,总体疗效较好,安全性较好,治疗胰十二指肠切除术后革兰阳性菌腹腔感染患者效果明显。

OBJECTIVE To observe the efficacy and safety of teicoplanin in treatment of abdominal infection caused by gram-positive bacteria after pancreaticoduodenectomy.METHODS A total of 68 patients who underwent the pancreaticoduodenectomy from Dec 2013 to Dec 2016 and had postoperative abdominal infections were enrolled in the study and randomly divided into the observation group and the control group,with 34 cases in each group.The observation group was treated with teicoplanin,and the control group was treated with vancomycin.The clinical efficacies of the two kinds of antibiotics and incidence of adverse reactions were observed and compared between the two groups of patients.RESULTS The cure rate of the observation group was 88.24%,the control group 94.12%,and there was no significant difference between the two groups.The incidence of adverse reactions was 8.82%in the observation group,29.41%in the control group,and there was significant difference between the two groups（P〈0.05）.CONCLUSION Teicoplanin is highly sensitive and safe in the treatment of the patients with gram-positive cocci abdominal infections after the pancreaticoduodenectomy and can achieve remarkable effect on treatment of the patients with gram-positive bacteria abdominal infection after the pancreaticoduodenectomy,with the total efficacy favorable.